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Kidney function and obstructive lung disease: a bidirectional Mendelian randomisation study
DC Field | Value | Language |
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dc.contributor.author | Park, Sehoon | - |
dc.contributor.author | Lee, Soojin | - |
dc.contributor.author | Kim, Yaerim | - |
dc.contributor.author | Cho, Semin | - |
dc.contributor.author | Kim, Kwangsoo | - |
dc.contributor.author | Kim, Yong Chul | - |
dc.contributor.author | Han, Seung Seok | - |
dc.contributor.author | Lee, Hajeong | - |
dc.contributor.author | Lee, Jung Pyo | - |
dc.contributor.author | Joo, Kwon Wook | - |
dc.contributor.author | Lim, Chun Soo | - |
dc.contributor.author | Kim, Yon Su | - |
dc.contributor.author | Kim, Dong Ki | - |
dc.date.accessioned | 2024-08-08T01:23:08Z | - |
dc.date.available | 2024-08-08T01:23:08Z | - |
dc.date.created | 2022-02-11 | - |
dc.date.created | 2022-02-11 | - |
dc.date.issued | 2021-12 | - |
dc.identifier.citation | European Respiratory Journal, Vol.58 No.6, p. 2100848 | - |
dc.identifier.issn | 0903-1936 | - |
dc.identifier.uri | https://hdl.handle.net/10371/205577 | - |
dc.description.abstract | Background Additional study is warranted to investigate the causal effects between kidney function and obstructive lung disease. Methods This study was a bidirectional two-sample Mendelian randomisation (MR) analysis. The Chronic Kidney Disease Genetics (CKDGen) genome-wide association study (GWAS) meta-analysis for estimated glomerular filtration rate (eGFR) including individuals of European ancestry (n=567 460) provided the genetic instrument for kidney function and outcome summary statistics. A GWAS for forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) including individuals of European ancestry from the UK Biobank (n=321 047) provided the genetic instrument for FEV1/FVC and outcome data. A polygenic score (PGS) analysis was performed to test the causal estimates from kidney function to binary obstructive lung disease outcomes, including COPD, asthma and FEV1/FVC <70%, and to perform nonlinear MR with individual-level UK Biobank data. Results The causal estimates by summary-level MR indicated that genetically predicted increased kidney function was significantly associated with increased FEV1/FVC z-scores (10% increase in eGFR; beta=0.055, 95% CI 0.024-0.086). The PGS for increased eGFR showed a significant association with a reduced risk of FEV1/FVC <70% (OR 0.93, 95% CI 0.87-0.99), COPD (OR 0.93, 95% CI 0.87-0.99) and late-onset (age > 50 years) asthma (OR 0.93, 95% CI 0.88-0.99). The nonlinear MR demonstrated that the causal effect from eGFR to FEV1/FVC was apparent in eGFR ranges <60 mL.min(-1).1.73 m(-2). Conversely, genetically predicted FEV1/FVC showed nonsignificant causal estimates of eGFR change (beta=0.568%, 95% CI -0.458-1.605%). Conclusion This study supports kidney function impairment as a causative factor for obstructive lung disease. | - |
dc.language | 영어 | - |
dc.publisher | European Respiratory Society | - |
dc.title | Kidney function and obstructive lung disease: a bidirectional Mendelian randomisation study | - |
dc.type | Article | - |
dc.identifier.doi | 10.1183/13993003.00848-2021 | - |
dc.citation.journaltitle | European Respiratory Journal | - |
dc.identifier.wosid | 000744140100021 | - |
dc.identifier.scopusid | 2-s2.0-85113293824 | - |
dc.citation.number | 6 | - |
dc.citation.startpage | 2100848 | - |
dc.citation.volume | 58 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Lee, Jung Pyo | - |
dc.contributor.affiliatedAuthor | Joo, Kwon Wook | - |
dc.contributor.affiliatedAuthor | Lim, Chun Soo | - |
dc.contributor.affiliatedAuthor | Kim, Yon Su | - |
dc.contributor.affiliatedAuthor | Kim, Dong Ki | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | PULMONARY-FUNCTION | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | HEALTH | - |
dc.subject.keywordPlus | RISK | - |
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