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Novel Hybrid Molecules Based on (-)-Epigallocatechin Gallate as Potent Anti-adipogenic Agents
Cited 2 time in
Web of Science
Cited 2 time in Scopus
- Authors
- Issue Date
- 2020-12
- Publisher
- Pharmaceutical Society of Japan
- Citation
- Chemical and Pharmaceutical Bulletin, Vol.68 No.12, pp.1155-1162
- Abstract
- A series of novel (-)-epigallocatechin gallate (EGCG)-phloroglucinol hybrid compounds 1-4 has been successfully synthesized by employing a simple and efficient methodology using a dielectric barrier discharge (DBD) plasma irradiation. The new hybrid structures were determined by interpretation of spectroscopic data, with the absolute configurations being established by analysis of the circular dichroism (CD) spectra. The novel hybrids 1 and 2 showed highly improved anti-adipogenic potencies toward both pancreatic lipase and preadipocytes differentiation in 3T3-L1 compared to the original EGCG and phloroglucinol. A novel hybrid 1 represent an interesting subclass of anti-adipogenic candidates that need further research.
- ISSN
- 0009-2363
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Related Researcher
- College of Agriculture and Life Sciences
- Department of Agricultural Biotechnology
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