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Etamycin as a Novel Mycobacterium abscessus Inhibitor
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hanh, Bui Thi Bich | - |
dc.contributor.author | Kim, Tae Ho | - |
dc.contributor.author | Park, June-Woo | - |
dc.contributor.author | Lee, Da-Gyum | - |
dc.contributor.author | Kim, Jae-Sung | - |
dc.contributor.author | Du, Young Eun | - |
dc.contributor.author | Yang, Chul-Su | - |
dc.contributor.author | Oh, Dong-Chan | - |
dc.contributor.author | Jang, Jichan | - |
dc.date.accessioned | 2024-08-08T01:25:50Z | - |
dc.date.available | 2024-08-08T01:25:50Z | - |
dc.date.created | 2020-11-09 | - |
dc.date.created | 2020-11-09 | - |
dc.date.issued | 2020-09 | - |
dc.identifier.citation | International Journal of Molecular Sciences, Vol.21 No.18, pp.6908-14 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://hdl.handle.net/10371/205919 | - |
dc.description.abstract | The increase in drug-resistantMycobacterium abscessus, which has become resistant to existing standard-of-care agents, is a major concern, and new antibacterial agents are strongly needed. In this study, we introduced etamycin that showed an excellent activity againstM. abscessus. We found that etamycin significantly inhibited the growth ofM. abscessuswild-type strain, three subspecies, and clinical isolates in vitro and inhibited the growth ofM. abscessusthat resides in macrophages without cytotoxicity. Furthermore, the in vivo efficacy of etamycin in the zebrafish (Danio rerio) infection model was greater than that of clarithromycin, which is recommended as the core agent for treatingM. abscessusinfections. Thus, we concluded that etamycin is a potential anti-M. abscessuscandidate for further development as a clinical drug candidate. | - |
dc.language | 영어 | - |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | - |
dc.title | Etamycin as a Novel Mycobacterium abscessus Inhibitor | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/ijms21186908 | - |
dc.citation.journaltitle | International Journal of Molecular Sciences | - |
dc.identifier.wosid | 000579930400001 | - |
dc.identifier.scopusid | 2-s2.0-85091406516 | - |
dc.citation.endpage | 14 | - |
dc.citation.number | 18 | - |
dc.citation.startpage | 6908 | - |
dc.citation.volume | 21 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Oh, Dong-Chan | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | MYCOBACTERIUM-ABSCESSUS | - |
dc.subject.keywordAuthor | Mycobacterium abscessus | - |
dc.subject.keywordAuthor | drug resistance | - |
dc.subject.keywordAuthor | novel drug discovery | - |
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