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Etamycin as a Novel Mycobacterium abscessus Inhibitor

Cited 10 time in Web of Science Cited 10 time in Scopus
Authors

Hanh, Bui Thi Bich; Kim, Tae Ho; Park, June-Woo; Lee, Da-Gyum; Kim, Jae-Sung; Du, Young Eun; Yang, Chul-Su; Oh, Dong-Chan; Jang, Jichan

Issue Date
2020-09
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
Citation
International Journal of Molecular Sciences, Vol.21 No.18, pp.6908-14
Abstract
The increase in drug-resistantMycobacterium abscessus, which has become resistant to existing standard-of-care agents, is a major concern, and new antibacterial agents are strongly needed. In this study, we introduced etamycin that showed an excellent activity againstM. abscessus. We found that etamycin significantly inhibited the growth ofM. abscessuswild-type strain, three subspecies, and clinical isolates in vitro and inhibited the growth ofM. abscessusthat resides in macrophages without cytotoxicity. Furthermore, the in vivo efficacy of etamycin in the zebrafish (Danio rerio) infection model was greater than that of clarithromycin, which is recommended as the core agent for treatingM. abscessusinfections. Thus, we concluded that etamycin is a potential anti-M. abscessuscandidate for further development as a clinical drug candidate.
ISSN
1661-6596
URI
https://hdl.handle.net/10371/205919
DOI
https://doi.org/10.3390/ijms21186908
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  • College of Pharmacy
  • Department of Manufacturing Pharmacy
Research Area Chemical biology of natural products, Drug discovery from microbial natural products, Study of insect-microbial symbiosis, 미생물 유래 생리활성 천연물 발굴, 천연물 구조 분석

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