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Efficient dimerization of (-)-epigallocatechin gallate using nonthermal plasma as potent melanogenesis inhibitors
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeong, Gyeong Han | - |
dc.contributor.author | Kim, Dong Hee | - |
dc.contributor.author | Jo, Cheorun | - |
dc.contributor.author | Park, Seungil | - |
dc.contributor.author | Kim, Seong Bong | - |
dc.contributor.author | Kim, Tae Hoon | - |
dc.date.accessioned | 2024-08-08T01:26:43Z | - |
dc.date.available | 2024-08-08T01:26:43Z | - |
dc.date.created | 2020-06-02 | - |
dc.date.created | 2020-06-02 | - |
dc.date.issued | 2020-07 | - |
dc.identifier.citation | Journal of Physics D: Applied Physics, Vol.53 No.27, p. 274005 | - |
dc.identifier.issn | 0022-3727 | - |
dc.identifier.uri | https://hdl.handle.net/10371/205961 | - |
dc.description.abstract | (-)-Epigallocatechin gallate (EGCG), which is the most abundant bitter polyphenol in green tea (Camellia sinensis) leaves, is generally unstable under oxidative conditions. In this study, the efficient dimerization of EGCG was successfully achieved without changes in stereochemistry by treatment with nonthermal dielectric barrier discharge (DBD) plasma. The stereochemically pure dimers 2 and 3 connected by a methylene linkage exhibited significantly enhanced melanogenesis inhibitory activities compared to the parent EGCG and the active compounds 2 and 3 suppressed cellular tyrosinase, tyrosinase-related protein (TRP)-1, and TRP-2 expression in B16F10 melanoma cells, which could be considered one of the mechanisms of action. These results indicate a new method for efficient dimerization of stereochemically active depigment agent induced by DBD plasma treatment. | - |
dc.language | 영어 | - |
dc.publisher | Institute of Physics Publishing | - |
dc.title | Efficient dimerization of (-)-epigallocatechin gallate using nonthermal plasma as potent melanogenesis inhibitors | - |
dc.type | Article | - |
dc.identifier.doi | 10.1088/1361-6463/ab8417 | - |
dc.citation.journaltitle | Journal of Physics D: Applied Physics | - |
dc.identifier.wosid | 000534268400001 | - |
dc.identifier.scopusid | 2-s2.0-85085727461 | - |
dc.citation.number | 27 | - |
dc.citation.startpage | 274005 | - |
dc.citation.volume | 53 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Jo, Cheorun | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | TEA POLYPHENOLS | - |
dc.subject.keywordPlus | GREEN TEA | - |
dc.subject.keywordPlus | OOLONGHOMOBISFLAVAN | - |
dc.subject.keywordPlus | BIOTRANSFORMATION | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | FLAVONOIDS | - |
dc.subject.keywordPlus | PHLORHIZIN | - |
dc.subject.keywordPlus | QUERCETIN | - |
dc.subject.keywordPlus | PRESSURE | - |
dc.subject.keywordPlus | MELANOMA | - |
dc.subject.keywordAuthor | (-)-Epigallocatechin gallate | - |
dc.subject.keywordAuthor | dimerization | - |
dc.subject.keywordAuthor | methylene bridge | - |
dc.subject.keywordAuthor | dielectric barrier discharge plasma | - |
dc.subject.keywordAuthor | anti-melanogenic activity | - |
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- College of Agriculture and Life Sciences
- Department of Agricultural Biotechnology
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