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MEST-C pathological score and long-term outcomes of child and adult patients with Henoch-Schonlein purpura nephritis
DC Field | Value | Language |
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dc.contributor.author | Yun, Donghwan | - |
dc.contributor.author | Kim, Dong Ki | - |
dc.contributor.author | Oh, Kook-Hwan | - |
dc.contributor.author | Joo, Kwon Wook | - |
dc.contributor.author | Moon, Kyung Chul | - |
dc.contributor.author | Kim, Yon Su | - |
dc.contributor.author | Lee, Kyoungbun | - |
dc.contributor.author | Han, Seung Seok | - |
dc.date.accessioned | 2024-08-08T01:27:57Z | - |
dc.date.available | 2024-08-08T01:27:57Z | - |
dc.date.created | 2020-05-20 | - |
dc.date.created | 2020-05-20 | - |
dc.date.issued | 2020-01 | - |
dc.identifier.citation | BMC Nephrology, Vol.21 No.1, p. 33 | - |
dc.identifier.issn | 1471-2369 | - |
dc.identifier.uri | https://hdl.handle.net/10371/206075 | - |
dc.description.abstract | BackgroundHenoch-Schonlein purpura nephritis (HSPN), a small-vessel vasculitis, shares renal pathological features with immunoglobulin A nephropathy. Oxford classification of immunoglobulin A nephropathy pathology has been updated to the MEST-C score, but its application in HSPN remains unresolved.MethodsTwo hundred and thirteen patients with biopsy-proven HSPN were retrieved from the Seoul National University Hospital between 2000 and 2017. Renal outcome risks (i.e., end-stage renal disease or doubling of serum creatinine) were evaluated according to MEST-C scores after stratification by age: 113 children aged <18years (9.23.6years) and 100 adults aged 18years (38.618.3years). We pooled our data with four previous cohort studies in which MEST or MEST-C scores were described in detail.Results Twenty-one child (19%) and 16 adult (16%) patients reached the renal outcome during the median follow-up periods of 12years and 13years, respectively (maximum 19years). In children, M1 and T1/T2 scores revealed worse renal outcomes than did M0 and T0 scores, respectively, whereas the T score was the only factor related to worse outcomes in adult patients after adjusting for multiple clinical and laboratory variables. The pooled data showed that M1, S1, and T1/T2 in children and E1 and T1/T2 in adults were correlated with poorer renal outcomes than those of their counterpart scores.Conclusions The Oxford classification MEST-C scores can predict long-term renal outcomes in patients with HSPN. | - |
dc.language | 영어 | - |
dc.publisher | BioMed Central | - |
dc.title | MEST-C pathological score and long-term outcomes of child and adult patients with Henoch-Schonlein purpura nephritis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1186/s12882-020-1691-5 | - |
dc.citation.journaltitle | BMC Nephrology | - |
dc.identifier.wosid | 000513505000003 | - |
dc.identifier.scopusid | 2-s2.0-85078711818 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 33 | - |
dc.citation.volume | 21 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Kim, Dong Ki | - |
dc.contributor.affiliatedAuthor | Oh, Kook-Hwan | - |
dc.contributor.affiliatedAuthor | Joo, Kwon Wook | - |
dc.contributor.affiliatedAuthor | Moon, Kyung Chul | - |
dc.contributor.affiliatedAuthor | Kim, Yon Su | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | IGA NEPHROPATHY | - |
dc.subject.keywordPlus | OXFORD CLASSIFICATION | - |
dc.subject.keywordPlus | FEATURES | - |
dc.subject.keywordAuthor | End-stage renal disease | - |
dc.subject.keywordAuthor | Henoch-Schonlein purpura nephritis | - |
dc.subject.keywordAuthor | MEST-C | - |
dc.subject.keywordAuthor | Oxford classification | - |
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