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Bombyxamycins A and B, Cytotoxic Macrocyclic Lactams from an Intestinal Bacterium of the Silkworm Bombyx mori

DC Field Value Language
dc.contributor.authorShin, Yern-Hyerk-
dc.contributor.authorBeom, Ji Yoon-
dc.contributor.authorChung, Beomkoo-
dc.contributor.authorShin, Yoonho-
dc.contributor.authorByun, Woong Sub-
dc.contributor.authorMoon, Kyuho-
dc.contributor.authorBae, Munhyung-
dc.contributor.authorLee, Sang Kook-
dc.contributor.authorOh, Ki-Bong-
dc.contributor.authorShin, Jongheon-
dc.contributor.authorYoon, Yeo Joon-
dc.contributor.authorOh, Dong-Chan-
dc.date.accessioned2024-08-08T01:30:04Z-
dc.date.available2024-08-08T01:30:04Z-
dc.date.created2019-11-07-
dc.date.created2019-11-07-
dc.date.issued2019-03-
dc.identifier.citationOrganic Letters, Vol.21 No.6, pp.1804-1808-
dc.identifier.issn1523-7060-
dc.identifier.urihttps://hdl.handle.net/10371/206295-
dc.description.abstractBombyxamycins A and B (1 and 2) were discovered from a silkworm gut Streptomyces bacterium. Spectroscopic analysis and multiple-step chemical derivatization identified them as 26-membered cyclic lactams with polyene features. Bombyxamycin A showed significant antibacterial and antiproliferative effects. The bombyxamycin biosynthetic gene cluster was identified by genetic analysis. Gene deletion experiments confirmed that the cytochrome P450 BomK is responsible for the generation of 2, which unprecedentedly bears tetrahydrofuran in its macrocyclic ring.-
dc.language영어-
dc.publisherAmerican Chemical Society-
dc.titleBombyxamycins A and B, Cytotoxic Macrocyclic Lactams from an Intestinal Bacterium of the Silkworm Bombyx mori-
dc.typeArticle-
dc.identifier.doi10.1021/acs.orglett.9b00384-
dc.citation.journaltitleOrganic Letters-
dc.identifier.wosid000461843900054-
dc.identifier.scopusid2-s2.0-85062484412-
dc.citation.endpage1808-
dc.citation.number6-
dc.citation.startpage1804-
dc.citation.volume21-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorLee, Sang Kook-
dc.contributor.affiliatedAuthorOh, Ki-Bong-
dc.contributor.affiliatedAuthorShin, Jongheon-
dc.contributor.affiliatedAuthorYoon, Yeo Joon-
dc.contributor.affiliatedAuthorOh, Dong-Chan-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusGUT BACTERIUM-
dc.subject.keywordPlusDUNG BEETLE-
dc.subject.keywordPlusABSOLUTE-CONFIGURATION-
dc.subject.keywordPlusCYCLIC-PEPTIDES-
dc.subject.keywordPlusGENE-CLUSTER-
dc.subject.keywordPlusBIOSYNTHESIS-
dc.subject.keywordPlusMACROLACTAMS-
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  • College of Pharmacy
  • Department of Manufacturing Pharmacy
Research Area Chemical biology of natural products, Drug discovery from microbial natural products, Study of insect-microbial symbiosis, 미생물 유래 생리활성 천연물 발굴, 천연물 구조 분석

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