A green chemical oligomerization of phloroglucinol induced by plasma as novel α-glucosidase inhibitors

Abstract

A new facile method was developed for simple green synthesis of methylene-bridged phloroglucinol oligomers using nonthermal dielectric barrier discharge (DBD) plasma in methanolic solution. The chemical structures of these newly generated oligomers 2-5 were determined by interpretation of the spectroscopic data, and the inhibitory activity toward alpha-glucosidase of all isolates was evaluated. The unusual phloroglcuinol pentamer 5 connected by four methylene linkages showed a much higher potential inhibitory effect against aglucosidase than the other generated oligomers 2-4 and appeared to be a promising lead for development as a potential antidiabetic agent.