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Cyclopeptides from the Sponge Stylissa flabelliformis

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dc.contributor.authorKwon, Oh-Seok-
dc.contributor.authorKim, Chang-Kwon-
dc.contributor.authorByun, Woong Sub-
dc.contributor.authorOh, Joonseok-
dc.contributor.authorLee, Yeon-Ju-
dc.contributor.authorLee, Hyi-Seung-
dc.contributor.authorSim, Chung J.-
dc.contributor.authorOh, Dong-Chan-
dc.contributor.authorLee, Sang Kook-
dc.contributor.authorOh, Ki-Bong-
dc.contributor.authorShin, Jongheon-
dc.date.accessioned2024-08-08T01:31:41Z-
dc.date.available2024-08-08T01:31:41Z-
dc.date.created2019-03-28-
dc.date.created2019-03-28-
dc.date.issued2018-06-
dc.identifier.citationJournal of Natural Products, Vol.81 No.6, pp.1426-1434-
dc.identifier.issn0163-3864-
dc.identifier.urihttps://hdl.handle.net/10371/206486-
dc.description.abstractThree new cyclopeptides, phakellistatins 20-22 (1-3), as well as 10 known cyclopeptides of the same structural class were isolated from the tropical sponge Stylissa flabelliformis. By a combination of chemical and spectroscopic methods, the structures of the new compounds were determined to be an epimeric mixture of cycloheptapeptides (1) and two epimeric cyclodecapeptides (2 and 3) related to the phakellistatins. The cyclopeptides were evaluated for in vitro cytotoxicity against a variety of cancer cell lines, and compounds 2 and 3 exhibited significant activity.-
dc.language영어-
dc.publisherAmerican Chemical Society-
dc.titleCyclopeptides from the Sponge Stylissa flabelliformis-
dc.typeArticle-
dc.identifier.doi10.1021/acs.jnatprod.8b00121-
dc.citation.journaltitleJournal of Natural Products-
dc.identifier.wosid000436527100015-
dc.identifier.scopusid2-s2.0-85049037621-
dc.citation.endpage1434-
dc.citation.number6-
dc.citation.startpage1426-
dc.citation.volume81-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorOh, Dong-Chan-
dc.contributor.affiliatedAuthorLee, Sang Kook-
dc.contributor.affiliatedAuthorOh, Ki-Bong-
dc.contributor.affiliatedAuthorShin, Jongheon-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusARCHIPELAGO MARINE SPONGE-
dc.subject.keywordPlusANTINEOPLASTIC AGENTS-
dc.subject.keywordPlusCYCLIC HEPTAPEPTIDES-
dc.subject.keywordPlusPHAKELLIA SP-
dc.subject.keywordPlusB-D-
dc.subject.keywordPlusPEPTIDES-
dc.subject.keywordPlusPROLINE-
dc.subject.keywordPlusMETHIONINE-
dc.subject.keywordPlusCARTERI-
dc.subject.keywordPlusDECAPEPTIDES-
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  • College of Pharmacy
  • Department of Manufacturing Pharmacy
Research Area Chemical biology of natural products, Drug discovery from microbial natural products, Study of insect-microbial symbiosis, 미생물 유래 생리활성 천연물 발굴, 천연물 구조 분석

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