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Borrelidins C-E: New antibacterial macrolides from a saltern-derived halophilic Nocardiopsis sp.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jungwoo | - |
dc.contributor.author | Shin, Daniel | - |
dc.contributor.author | Kim, Seong-Hwan | - |
dc.contributor.author | Park, Wanki | - |
dc.contributor.author | Shin, Yoonho | - |
dc.contributor.author | Kim, Won Kyung | - |
dc.contributor.author | Lee, Sang Kook | - |
dc.contributor.author | Oh, Ki-Bong | - |
dc.contributor.author | Shin, Jongheon | - |
dc.contributor.author | Oh, Dong-Chan | - |
dc.date.accessioned | 2024-08-08T01:33:52Z | - |
dc.date.available | 2024-08-08T01:33:52Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2017-06 | - |
dc.identifier.citation | Marine Drugs, Vol.15 No.6, p. 166 | - |
dc.identifier.issn | 1660-3397 | - |
dc.identifier.uri | https://hdl.handle.net/10371/206709 | - |
dc.description.abstract | Chemical investigation of a halophilic actinomycete strain belonging to the genus Nocardiopsis inhabiting a hypersaline saltern led to the discovery of new 18-membered macrolides with nitrile functionality, borrelidins C-E (1-3), along with a previously reported borrelidin (4). The planar structures of borrelidins C-E, which are new members of the rare borrelidin class of antibiotics, were elucidated by NMR, mass, IR, and UV spectroscopic analyses. The configurations of borrelidines C-E were determined by the interpretation of ROESY NMR spectra, J-based configuration analysis, a modified Mosher's method, and CD spectroscopic analysis. Borrelidins C and D displayed inhibitory activity, particularly against the Gram-negative pathogen Salmonella enterica, and moderate cytotoxicity against the SNU638 and K562 carcinoma cell lines. | - |
dc.language | 영어 | - |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | - |
dc.title | Borrelidins C-E: New antibacterial macrolides from a saltern-derived halophilic Nocardiopsis sp. | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/md15060166 | - |
dc.citation.journaltitle | Marine Drugs | - |
dc.identifier.wosid | 000404526900021 | - |
dc.identifier.scopusid | 2-s2.0-85020785010 | - |
dc.citation.number | 6 | - |
dc.citation.startpage | 166 | - |
dc.citation.volume | 15 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Lee, Sang Kook | - |
dc.contributor.affiliatedAuthor | Oh, Ki-Bong | - |
dc.contributor.affiliatedAuthor | Shin, Jongheon | - |
dc.contributor.affiliatedAuthor | Oh, Dong-Chan | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ACTINOMYCETE | - |
dc.subject.keywordPlus | DISCOVERY | - |
dc.subject.keywordAuthor | antibacterial | - |
dc.subject.keywordAuthor | saltern | - |
dc.subject.keywordAuthor | halophilic actinomycetes | - |
dc.subject.keywordAuthor | borrelidin | - |
dc.subject.keywordAuthor | Salmonella enterica | - |
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