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Naphthoquinone-oxindole alkaloids, coprisidins A and B, from a gut-associated bacterium in the dung beetle, Copris tripartitus

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dc.contributor.authorUm, Soohyun-
dc.contributor.authorBach, Duc-Hiep-
dc.contributor.authorShin, Bora-
dc.contributor.authorAhn, Chan-Hong-
dc.contributor.authorKim, Seong-Hwan-
dc.contributor.authorBang, Hea-Son-
dc.contributor.authorOh, Ki-Bong-
dc.contributor.authorLee, Sang Kook-
dc.contributor.authorShin, Jongheon-
dc.contributor.authorOh, Dong-Chan-
dc.date.accessioned2024-08-08T01:35:37Z-
dc.date.available2024-08-08T01:35:37Z-
dc.date.created2017-11-15-
dc.date.created2017-11-15-
dc.date.issued2016-11-
dc.identifier.citationOrganic Letters, Vol.18 No.22, pp.5792-5795-
dc.identifier.issn1523-7060-
dc.identifier.urihttps://hdl.handle.net/10371/206858-
dc.description.abstractCoprisidins A and B (1 and 2) were isolated from a gut -associated Streptomyces sp. in the dung beetle Copris tripartitus. Using a combination of spectroscopic techniques, the structures of the compounds were determined to be the first examples of natural naphthoquinone oxindole alkaloids. Coprisidin A was found to inhibit the action of Na+/K+-ATPase, and coprisidin B showed activity for the induction of NAD(P)H:quinone oxidoreductase 1.-
dc.language영어-
dc.publisherAmerican Chemical Society-
dc.titleNaphthoquinone-oxindole alkaloids, coprisidins A and B, from a gut-associated bacterium in the dung beetle, Copris tripartitus-
dc.typeArticle-
dc.identifier.doi10.1021/acs.orglett.6b02555-
dc.citation.journaltitleOrganic Letters-
dc.identifier.wosid000388428600006-
dc.identifier.scopusid2-s2.0-84996599712-
dc.citation.endpage5795-
dc.citation.number22-
dc.citation.startpage5792-
dc.citation.volume18-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorOh, Ki-Bong-
dc.contributor.affiliatedAuthorLee, Sang Kook-
dc.contributor.affiliatedAuthorShin, Jongheon-
dc.contributor.affiliatedAuthorOh, Dong-Chan-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusNATURAL-PRODUCTS-
dc.subject.keywordPlusSTREPTOMYCES SP-
dc.subject.keywordPlusBIOSYNTHESIS-
dc.subject.keywordPlusPOLYKETIDE-
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  • College of Pharmacy
  • Department of Manufacturing Pharmacy
Research Area Chemical biology of natural products, Drug discovery from microbial natural products, Study of insect-microbial symbiosis, 미생물 유래 생리활성 천연물 발굴, 천연물 구조 분석

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