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Callyazepin and (3R)-methylazacyclodecane, nitrogenous macrocycles from a callyspongia sp sponge
Cited 11 time in
Web of Science
Cited 13 time in Scopus
- Authors
- Issue Date
- 2016-04
- Publisher
- American Chemical Society
- Citation
- Journal of Natural Products, Vol.79 No.4, pp.1179-1183
- Abstract
- Callyazepin (1) and (3R)-methylazacyclodecane (2), nitrogenous macrocycles, were isolated from a tropical Callyspongia sp. sponge. The combined spectroscopic analyses revealed that the structure of 1 is a bicyclic azepane ammonium salt of a novel structural class derived from mixed biogenetic origins. The configuration of the whole molecule and the conformation of the formamide group were assigned by proton-proton coupling constants, a NOESY analysis, and the application of the phenylglycine methyl ester method. The structure of 2 was identified using combined spectroscopic analyses and ECD measurements. These compounds exhibited moderate cytotoxic activities against the K562 and A549 cell lines.
- ISSN
- 0163-3864
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