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Clinical implication of protease-activated receptor-2 in idiopathic pulmonary fibrosis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Young Sik | - |
dc.contributor.author | Park, Chang Min | - |
dc.contributor.author | Lee, Hyun Ju | - |
dc.contributor.author | Goo, Jin Mo | - |
dc.contributor.author | Chung, Doo Hyun | - |
dc.contributor.author | Lee, Sang-Min | - |
dc.contributor.author | Yim, Jae-Joon | - |
dc.contributor.author | Kim, Young Whan | - |
dc.contributor.author | Han, Sung Koo | - |
dc.contributor.author | Yoo, Chul-Gyu | - |
dc.date.accessioned | 2024-08-08T01:44:14Z | - |
dc.date.available | 2024-08-08T01:44:14Z | - |
dc.date.created | 2021-02-16 | - |
dc.date.created | 2021-02-16 | - |
dc.date.created | 2021-02-16 | - |
dc.date.issued | 2013-02 | - |
dc.identifier.citation | Respiratory Medicine, Vol.107 No.2, pp.256-262 | - |
dc.identifier.issn | 0954-6111 | - |
dc.identifier.uri | https://hdl.handle.net/10371/207700 | - |
dc.description.abstract | Idiopathic pulmonary fibrosis (IPF) is a lethal pulmonary disease which is characterized by progressive fibrosis. In general, the exaggerated activation of the coagulation cascade has been observed during initiation or maintenance of the fibrotic disease. In a recent study, protease-activated receptor (PAR)-2, which plays a key role in coagulation cascade, was up-regulated in IPF patients, however, its clinical implications have not been understood. The objective of the present study was to evaluate the clinical significance of PAR-2 expression in the alveolar epithelial cells of IPF patients. PAR-2 expression was evaluated by immunohistochemical method in formalin-fixed and paraffin-embedded tissues of surgical lung biopsies from patients with IPF. Fibrosis scores from hematoxylin and eosin-stained lung sections and honeycombing scores in chest CT were calculated. Medical records were retrospectively reviewed and the correlation between the expression of PAR-2 and clinical profiles were assessed. Among thirty-three IPF patients, PAR-2 expression was observed in 25 (75.8%). The lymphocyte counts in peripheral blood (2317 vs. 1753, p = 0.044) and honeycombing scores in chest CT (4.0 vs. 3.0 p = 0.046) were higher in PAR-2 positive group compared with PAR-2 negative group. During a follow-up duration of median 40.3 months, 7 (21.2%) patients died and they were all included in the PAR-2 positive group (p = 0.113). We conclude that PAR-2 is expressed in the alveolar epithelial cells of a substantial number of IPF patients, and the expression of PAR-2 significantly correlates with the extent of honeycombing shown in chest CT. (C) 2012 Elsevier Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | W. B. Saunders Co., Ltd. | - |
dc.title | Clinical implication of protease-activated receptor-2 in idiopathic pulmonary fibrosis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.rmed.2012.10.011 | - |
dc.citation.journaltitle | Respiratory Medicine | - |
dc.identifier.wosid | 000314556000012 | - |
dc.identifier.scopusid | 2-s2.0-84872102581 | - |
dc.citation.endpage | 262 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | 256 | - |
dc.citation.volume | 107 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Park, Chang Min | - |
dc.contributor.affiliatedAuthor | Goo, Jin Mo | - |
dc.contributor.affiliatedAuthor | Chung, Doo Hyun | - |
dc.contributor.affiliatedAuthor | Lee, Sang-Min | - |
dc.contributor.affiliatedAuthor | Yim, Jae-Joon | - |
dc.contributor.affiliatedAuthor | Kim, Young Whan | - |
dc.contributor.affiliatedAuthor | Han, Sung Koo | - |
dc.contributor.affiliatedAuthor | Yoo, Chul-Gyu | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | MOLECULAR-CLONING | - |
dc.subject.keywordPlus | UP-REGULATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PROCOAGULANT | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | AIRWAYS | - |
dc.subject.keywordPlus | PAR-2 | - |
dc.subject.keywordAuthor | Honeycombing | - |
dc.subject.keywordAuthor | Idiopathic pulmonary fibrosis | - |
dc.subject.keywordAuthor | Mortality | - |
dc.subject.keywordAuthor | Protease-activated receptor | - |
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