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Acremolin, a new 1H-azirine metabolite from the marine-derived fungus Acremonium strictum
Cited 33 time in
Web of Science
Cited 33 time in Scopus
- Authors
- Issue Date
- 2012-06
- Publisher
- Elsevier BV
- Citation
- Tetrahedron Letters, Vol.53 No.23, pp.2885-2886
- Abstract
- Acremolin (1), a novel modified base, was isolated from the culture broth of the marine fungus Acremonium strictum. Based on combined spectroscopic analyses, the structure of this compound was that of a methyl guanine base containing an isoprene unit. In addition, the presence of a 1H-azirine moiety is unprecedented among natural products. This compound exhibited weak cytotoxicity against an A549 cell line. (C) 2012 Elsevier Ltd. All rights reserved.
- ISSN
- 0040-4039
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