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Circulating Levels of Vitamin D and Colon and Rectal Cancer: The Physicians' Health Study and a Meta-analysis of Prospective Studies
DC Field | Value | Language |
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dc.contributor.author | Lee, Jung Eun | - |
dc.contributor.author | Li, Haojie | - |
dc.contributor.author | Chan, Andrew T. | - |
dc.contributor.author | Hollis, Bruce W. | - |
dc.contributor.author | Lee, I-Min | - |
dc.contributor.author | Stampfer, Meir J. | - |
dc.contributor.author | Wu, Kana | - |
dc.contributor.author | Giovannucci, Edward | - |
dc.contributor.author | Ma, Jing | - |
dc.date.accessioned | 2024-08-08T01:46:11Z | - |
dc.date.available | 2024-08-08T01:46:11Z | - |
dc.date.created | 2024-06-19 | - |
dc.date.created | 2024-06-19 | - |
dc.date.issued | 2011-05 | - |
dc.identifier.citation | CANCER PREVENTION RESEARCH, Vol.4 No.5, pp.735-743 | - |
dc.identifier.issn | 1940-6207 | - |
dc.identifier.uri | https://hdl.handle.net/10371/207987 | - |
dc.description.abstract | It remains unknown whether increased risk with low levels of vitamin D is present for colon and/or rectal cancer. To investigate the association between circulating vitamin D levels and colon and rectal cancer, we examined the associations between plasma levels of 25-hydroxyvitamin D [25(OH)D] and 1,25-dihydroxyvitamin D [1,25(OH)2D] and colon and rectal cancer in the Physicians' Health Study and then conducted a meta-analysis of eight prospective studies of circulating levels of 25(OH)D and colon and rectal cancers, including the Physicians' Health Study. Study-specific ORs and 95% CIs were pooled by using a random-effects model. A total of 1,822 colon and 868 rectal cancers were included in the meta-analysis. We observed a significant inverse association for colorectal cancer (OR = 0.66; 95% Cl, 0.54-0.81), comparing top versus bottom quantiles of circulating 25(OH)D levels. The inverse association stronger for rectal cancer (OR = 0.50 for top versus bottom quantiles; 95% CI, 0.28-0.88) than colon cancer (OR = 0.77; 95% CI, 0.56-1.07; P value for difference between colon and rectal cancer = 0.20). These data suggest an inverse association between circulating 25(OH)D levels and colorectal cancer, with a stronger association for rectal cancer. Cancer Pier Res; 4(5); 735-43. (c) 2011 AACR. | - |
dc.language | 영어 | - |
dc.publisher | AMER ASSOC CANCER RESEARCH | - |
dc.title | Circulating Levels of Vitamin D and Colon and Rectal Cancer: The Physicians' Health Study and a Meta-analysis of Prospective Studies | - |
dc.type | Article | - |
dc.identifier.doi | 10.1158/1940-6207.CAPR-10-0289 | - |
dc.citation.journaltitle | CANCER PREVENTION RESEARCH | - |
dc.identifier.wosid | 000290201100014 | - |
dc.identifier.scopusid | 2-s2.0-79955805773 | - |
dc.citation.endpage | 743 | - |
dc.citation.number | 5 | - |
dc.citation.startpage | 735 | - |
dc.citation.volume | 4 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Lee, Jung Eun | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | COLORECTAL-CANCER | - |
dc.subject.keywordPlus | SUBSEQUENT RISK | - |
dc.subject.keywordPlus | VDR GENOTYPES | - |
dc.subject.keywordPlus | CALCIUM | - |
dc.subject.keywordPlus | PLASMA | - |
dc.subject.keywordPlus | 25-HYDROXYVITAMIN-D | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | PROSTATE | - |
dc.subject.keywordPlus | D-3 | - |
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