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Decreased phosphorylation of STAT-1, STAT-4 and cytokine release in MDR-TB patients with primary resistance

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dc.contributor.authorKim, H. J.-
dc.contributor.authorChung, D. H.-
dc.contributor.authorKim, M. J.-
dc.contributor.authorJang, J. H.-
dc.contributor.authorKim, Y. W.-
dc.contributor.authorHan, S. K.-
dc.contributor.authorShim, Y-S.-
dc.contributor.authorYim, J-J.-
dc.date.accessioned2024-08-08T01:48:55Z-
dc.date.available2024-08-08T01:48:55Z-
dc.date.created2023-07-25-
dc.date.created2023-07-25-
dc.date.issued2008-09-
dc.identifier.citationInternational Journal of Tuberculosis and Lung Disease, Vol.12 No.9, pp.1071-1076-
dc.identifier.issn1027-3719-
dc.identifier.urihttps://hdl.handle.net/10371/208344-
dc.description.abstractSETTING: We recently showed that treatment failure rate was higher among multidrug-resistant tuberculosis (MDR-TB) patients without a previous history of tuberculosis (TB) treatment, or so-called 'primary resistance'. OBJECTIVE: To investigate the phosphorylation levels of signal transducers and activators of transcription-1 (STAT-1) and STAT-4 and the subsequent cytokine release as a possible cause of a poor prognosis in MDR-TB patients with primary resistance. DESIGN: Ten patients with successfully treated pulmonary TB without resistance, 12 MDR-TB patients with acquired resistance and 10 MDR-TB patients with primary resistance were enrolled. After 24 h stimulation of peripheral blood mononuclear cells (PBMC) with interferon-gamma (IFN-gamma), interleukin-12 (IL-12), purified protein derivative (PPD), or lysate of Mycobacterium tuberculosis, flow cytometric analysis of intracellular pSTAT-1 and pSTAT-4 were performed and secretion of IFN-gamma, IL-12p40 and tumour necrosis factor-alpha (TNF-alpha) was measured in culture supernatant. RESULTS: The mean fluorescent intensities of pSTAT-1 and pSTAT-4 in PBMC of MDR-TB patients with primary resistance decreased on stimulation of IFN-gamma, PPD or lysate of M. tuberculosis when compared with patients with acquired resistance. In addition, secretion of IFN-gamma, IL-12p40 and TNF-alpha in these patients decreased on various stimuli. CONCLUSION: Decreased phosphorylation of STAT-1, STAT-4, and of subsequent cytokine release, might be associated with a poor prognosis in MDR-TB patients with primary resistance.-
dc.language영어-
dc.publisherInternational Union Against Tuberculosis And Lung Disease/Union Internationale Contre la Tuberculose et les Maladies Respiratories-
dc.titleDecreased phosphorylation of STAT-1, STAT-4 and cytokine release in MDR-TB patients with primary resistance-
dc.typeArticle-
dc.citation.journaltitleInternational Journal of Tuberculosis and Lung Disease-
dc.identifier.wosid000258857500016-
dc.identifier.scopusid2-s2.0-51149095389-
dc.citation.endpage1076-
dc.citation.number9-
dc.citation.startpage1071-
dc.citation.volume12-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorChung, D. H.-
dc.contributor.affiliatedAuthorShim, Y-S.-
dc.contributor.affiliatedAuthorYim, J-J.-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusINTERFERON-GAMMA-RECEPTOR-
dc.subject.keywordPlusMYCOBACTERIAL INFECTION-
dc.subject.keywordPlusTUBERCULOSIS-
dc.subject.keywordPlusDEFICIENCY-
dc.subject.keywordPlusMUTATION-
dc.subject.keywordPlusIMMUNITY-
dc.subject.keywordPlusSUSCEPTIBILITY-
dc.subject.keywordPlusIMPAIRMENT-
dc.subject.keywordPlusDOMINANT-
dc.subject.keywordPlusTHERAPY-
dc.subject.keywordAuthorMDR-TB-
dc.subject.keywordAuthorpSTAT-1-
dc.subject.keywordAuthorpSTAT-4-
dc.subject.keywordAuthorIFN-gamma-
dc.subject.keywordAuthorIL-12-
dc.subject.keywordAuthorTNF-alpha-
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  • College of Medicine
  • Department of Medicine
Research Area Nontuberculous Mycobacteria, Tuberculosis, multidrug-resistant tuberculosis, 결핵, 다제내성결핵, 비결핵항산균 폐질환

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