Publications

Detailed Information

Evidence of potential interaction of chemokine genes in susceptibility to systemic sclerosis

Cited 20 time in Web of Science Cited 19 time in Scopus
Authors

Lee, E. B.; Zhao, J.; Kim, J. Y.; Xiong, M.; Song, Y. W.

Issue Date
2007-06-30
Publisher
Wiley-Blackwell
Citation
Arthritis Rheum. 2007 Jul;56(7):2443-8.
Keywords
Chemokine CCL5Chemokines/*geneticsChemokines, CC/geneticsHumansInterleukin-8/geneticsKoreaReference ValuesScleroderma, Systemic/*geneticsGenetic Predisposition to DiseasePolymorphism, Single Nucleotide
Abstract
OBJECTIVE: To examine genetic polymorphisms in the chemokine pathway, and to assess their interactions in relation to susceptibility to systemic sclerosis (SSc). METHODS: To identify the risk of SSc conferred by genetic polymorphisms in the chemokine pathway, 10 single-nucleotide polymorphisms (SNPs) from 8 candidate genes were studied in 99 patients with SSc and 198 age- and sex-matched controls in a Korean population. SNPs were genotyped by polymerase chain reaction-restriction fragment length polymorphism or sequence-specific primer methods. Genetic associations between each SNP and SSc risk, calculated as odds ratios with 95% confidence intervals, were estimated using chi-square tests. Haplotypes for the 2 polymorphisms in the gene CCL5 (RANTES) were constructed, and their associations with SSc were tested. Gene-gene interactions were investigated using a recently described novel method, and the results were confirmed by conditional logistic regression. Adjustment for multiple testing was based on Bonferroni correction. RESULTS: There was significant evidence of gene-gene interaction between polymorphisms in the genes CXCL8 (interleukin-8) and CCL5, and both of these were associated with an increased risk of SSc. This SNP-SNP interaction was confirmed by 2 independent statistical methods. The associations remained significant after Bonferroni adjustment for multiple testing. No significant association between each individual SNP or haplotype and the risk of SSc was found. CONCLUSION: Crosstalk between the 2 chemokines CXCL8 and CCL5 may contribute to the susceptibility to SSc.
ISSN
0004-3591 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17599774

https://hdl.handle.net/10371/22394
DOI
https://doi.org/10.1002/art.22742
Files in This Item:
There are no files associated with this item.
Appears in Collections:

Altmetrics

Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Share