S-Space College of Medicine/School of Medicine (의과대학/대학원) Immunology (면역학전공) Journal Papers (저널논문_면역학전공)
Multilocus analysis of atopy in Korean children using multifactor-dimensionality reduction
- Park, H. W.; Shin, E. S.; Lee, J. E.; Kwon, H. S.; Chun, E.; Kim, S. S.; Chang, Y. S.; Kim, Y. K.; Min, K. U.; Kim, Y. Y.; Cho, S. H.
- Issue Date
- BMJ Publishing Group
- Thorax. 2007 Mar;62(3):265-9. Epub 2006 Nov 22.
- Adolescent; Child; Female; Gene Frequency; Genotype; Humans; Hypersensitivity, Immediate/epidemiology/*genetics; Korea/epidemiology; Male; Polymorphism, Single Nucleotide/*genetics; Regression Analysis; Vascular Endothelial Growth Factor Receptor-2/*genetics
- BACKGROUND: Atopy is considered to be a complex genetic trait and does not follow a simple mendelian pattern of inheritance. It is now well recognised that gene-gene interactions are important in complex genetic disease. AIM: To analyse the influence of gene-gene interactions in the development of atopy. METHODS: A total of 2055 ethnically identical participants aged 10-18 years living in rural areas on Jeju Island, Korea, were randomly recruited. Atopy was defined as a positive skin prick test response to one or more common inhalant allergens. Gene-gene interactions among 12 polymorphic loci were analysed in the seven candidate genes of atopy using the multidimensionality-reduction method. RESULTS: A significant interaction was found between V297I in the gene coding vascular endothelial growth factor receptor 2 (KDR) and -308G-->A in the gene coding tumour necrosis factor (TNF)alpha on the risk of atopy, with a cross-validation consistency of 10 out of 10 and a prediction error of 35.9% (p = 0.001). Conventional logistic regression also revealed significant interactions between KDR and TNF for atopy. Individuals with the variant allele of -308G-->A in TNF (GA or AA) and V297I in KDR (VI or II) had a significantly higher risk of atopy (OR 2.23; 95% CI 1.48 to 3.57). CONCLUSION: KDR and TNF may synergistically influence the development of atopy through gene-gene interaction in Korean children and adolescents.
- 0040-6376 (Print)