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Distinct expression patterns of E-cadherin and beta-catenin in signet ring cell carcinoma components of primary pulmonary adenocarcinoma

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Authors
Moon, K. C.; Cho, S. Y.; Lee, H. S.; Jeon, Y. K.; Chung, J. H.; Jung, K. C.; Chung, D. H.
Issue Date
2006-09-05
Publisher
College of American Pathologists
Citation
Arch Pathol Lab Med. 2006 Sep;130(9):1320-5.
Keywords
Adenocarcinoma/*pathologyAdultAgedCadherins/*metabolismCarcinoma, Signet Ring Cell/*pathologyColorectal Neoplasms/*pathologyFemaleHumansImmunohistochemistryLung Neoplasms/*pathologyMaleMiddle AgedRetrospective StudiesStomach Neoplasms/*pathologyTumor Markers, Biological/analysisbeta Catenin/*metabolism
Abstract
CONTEXT: E-Cadherin and beta-catenin complexes have been suggested to have critical roles in cancer development and progression. Primary signet ring cell carcinoma (SRCC) of the lung is a rare variant of pulmonary adenocarcinoma, and E-cadherin and beta-catenin expressions of this tumor have not been documented, to our knowledge. OBJECTIVE: To characterize the E-cadherin and beta-catenin expressions in SRCC of the lung. DESIGN: An immunohistochemical evaluation of E-cadherin and beta-catenin expressions in 10 cases of SRCC of the lung, 10 cases of conventional pulmonary adenocarcinoma, 10 cases of gastric SRCC, and 10 cases of colorectal SRCC was performed. RESULTS: Membranous E-cadherin and beta-catenin expressions were frequently reduced or absent in all types of tumors tested. Aberrant E-cadherin localization and nuclear beta-catenin accumulation were frequently found in gastric (6/10 and 5/10, respectively) and colorectal (7/10 and 9/ 10, respectively) SRCCs, whereas SRCC of the lung rarely showed aberrant E-cadherin localization (1/10) or nuclear beta-catenin accumulation (0/10). CONCLUSIONS: Signet ring cell carcinoma of the lung rarely showed aberrant E-cadherin localization or beta-catenin nuclear accumulation, which are frequent events in gastric and colorectal SRCCs. These results suggest that the biologic roles of E-cadherin and beta-catenin complexes in SRCC of the lung differ from their roles in gastric or colorectal SRCCs.
ISSN
1543-2165 (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16948518

https://hdl.handle.net/10371/22562
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College of Medicine/School of Medicine (의과대학/대학원)Immunology (면역학전공)Journal Papers (저널논문_면역학전공)
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