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The multi-step phosphorelay mechanism of unorthodox two-component systems in E. coli realizes ultrasensitivity to stimuli while maintaining robustness to noises

Cited 44 time in Web of Science Cited 42 time in Scopus
Authors
Kim, J. R.Cho, K. H.
Issue Date
2006-11-23
Publisher
Elsevier
Citation
Comput Biol Chem. 2006 Dec;30(6):438-44. Epub 2006 Nov 16.
Keywords
Cell SurvivalComputer SimulationEscherichia coli/chemistry/*metabolismEscherichia coli Proteins/*metabolismHistidine/*metabolismMathematicsPhosphorylationProtein Kinases/*metabolismNoiseSignal Transduction
Abstract
E. coli has two-component systems composed of histidine kinase proteins and response regulator proteins. For a given extracellular stimulus, a histidine kinase senses the stimulus, autophosphorylates and then passes the phosphates to the cognate response regulators. The histidine kinase in an orthodox two-component system has only one histidine domain where the autophosphorylation occurs, but a histidine kinase in some unusual two-component systems (unorthodox two-component systems) has two histidine domains and one aspartate domain. So, the unorthodox two-component systems have more complex phosphorelay mechanisms than orthodox two-component systems. In general, the two-component systems are required to promptly respond to external stimuli for survival of E. coli. In this respect, the complex multi-step phosphorelay mechanism seems to be disadvantageous, but there are several unorthodox two-component systems in E. coli. In this paper, we investigate the reason why such unorthodox two-component systems are present in E. coli. For this purpose, we have developed simplified mathematical models of both orthodox and unorthodox two-component systems and analyzed their dynamical characteristics through extensive computer simulations. We have finally revealed that the unorthodox two-component systems realize ultrasensitive responses to external stimuli and also more robust responses to noises than the orthodox two-component systems.
ISSN
1476-9271 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17112785

https://hdl.handle.net/10371/22578
DOI
https://doi.org/10.1016/j.compbiolchem.2006.09.004
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College of Medicine/School of Medicine (의과대학/대학원)Immunology (면역학전공)Journal Papers (저널논문_면역학전공)
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