S-Space College of Medicine/School of Medicine (의과대학/대학원) Immunology (면역학전공) Journal Papers (저널논문_면역학전공)
Regulation of IL-18 expression by CRH in mouse microglial cells
- Yang, Y.; Hahm, E.; Kim, Y.; Kang, J.; Lee, W.; Han, I.; Myung, P.; Kang, H.; Park, H.; Cho, D.
- Issue Date
- Immunol Lett. 2005 May 15;98(2):291-6. Epub 2004 Dec 30.
- Animals; Cells, Cultured; Corticotropin-Releasing Hormone/*pharmacology; Gene Expression Regulation/*drug effects; Interferon-gamma/biosynthesis/secretion; Interleukin-18/genetics/*metabolism; Mice; Mice, Inbred C57BL; Microglia/*drug effects/*metabolism; RNA, Messenger/genetics; Reactive Oxygen Species/metabolism; Receptors, Corticotropin-Releasing Hormone/genetics; Signal Transduction/drug effects; Titrimetry
- Corticotropin releasing hormone (CRH) is a major regulator of the stress response. This study examined whether CRH regulates interleukin-18 expression on microglia, BV2. Our data show that CRH enhanced IL-18 expression and significantly induced the secretion of functional IL-18 protein. Furthermore, CRH induced IL-18 production could be blocked by N-acetyl-L-cystein (NAC), which suggests that reactive oxygen intermediates (ROI) may be involved in regulating IL-18. Indeed, it was also found that CRH increased the generation of ROI. Taken together, these results indicate that CRH is an important mediator that regulates IL-18 expression in the brain during stress.
- 0165-2478 (Print)
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