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IL-4 increases type 2, but not type 1, cytokine production in CD8+ T cells from mild atopic asthmatics

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dc.contributor.authorStanciu, L. A.-
dc.contributor.authorRoberts, K.-
dc.contributor.authorPapadopoulos, N. G.-
dc.contributor.authorCho, S. H.-
dc.contributor.authorHolgate, S. T.-
dc.contributor.authorCoyle, A. J.-
dc.contributor.authorJohnston, S. L.-
dc.date.accessioned2009-12-24T11:13:46Z-
dc.date.available2009-12-24T11:13:46Z-
dc.date.issued2005-07-09-
dc.identifier.citationRespir Res. 2005 Jul 7;6:67.en
dc.identifier.issn1465-993X (Electronic)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16001979-
dc.identifier.urihttps://hdl.handle.net/10371/22603-
dc.description.abstractBACKGROUND: Virus infections are the major cause of asthma exacerbations. CD8+ T cells have an important role in antiviral immune responses and animal studies suggest a role for CD8+ T cells in the pathogenesis of virus-induced asthma exacerbations. We have previously shown that the presence of IL-4 during stimulation increases the frequency of IL-5-positive cells and CD30 surface staining in CD8+ T cells from healthy, normal subjects. In this study, we investigated whether excess IL-4 during repeated TCR/CD3 stimulation of CD8+ T cells from atopic asthmatic subjects alters the balance of type 1/type 2 cytokine production in favour of the latter. METHODS: Peripheral blood CD8+ T cells from mild atopic asthmatic subjects were stimulated in vitro with anti-CD3 and IL-2 +/- excess IL-4 and the expression of activation and adhesion molecules and type 1 and type 2 cytokine production were assessed. RESULTS: Surface expression of very late antigen-4 [VLA-4] and LFA-1 was decreased and the production of the type 2 cytokines IL-5 and IL-13 was augmented by the presence of IL-4 during stimulation of CD8+ T cells from mild atopic asthmatics. CONCLUSION: These data suggest that during a respiratory virus infection activated CD8+ T cells from asthmatic subjects may produce excess type 2 cytokines and may contribute to asthma exacerbation by augmenting allergic inflammation.en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.subjectAdulten
dc.subjectAsthma/classification/*immunology/pathologyen
dc.subjectCD8-Positive T-Lymphocytes/*immunologyen
dc.subjectCells, Cultureden
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectIntegrin alpha4beta1/*immunologyen
dc.subjectInterleukin-13/*immunologyen
dc.subjectInterleukin-4/*immunologyen
dc.subjectInterleukin-5/*immunologyen
dc.subjectLymphocyte Activation/immunologyen
dc.subjectLymphocyte Function-Associated Antigen-1/*immunologyen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectTh1 Cells/immunologyen
dc.subjectTh2 Cells/immunologyen
dc.titleIL-4 increases type 2, but not type 1, cytokine production in CD8+ T cells from mild atopic asthmaticsen
dc.typeArticleen
dc.contributor.AlternativeAuthor조상헌-
dc.identifier.doi10.1186/1465-9921-6-67-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Immunology (면역학전공)Journal Papers (저널논문_면역학전공)
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