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IL-4 increases type 2, but not type 1, cytokine production in CD8+ T cells from mild atopic asthmatics
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Stanciu, L. A. | - |
dc.contributor.author | Roberts, K. | - |
dc.contributor.author | Papadopoulos, N. G. | - |
dc.contributor.author | Cho, S. H. | - |
dc.contributor.author | Holgate, S. T. | - |
dc.contributor.author | Coyle, A. J. | - |
dc.contributor.author | Johnston, S. L. | - |
dc.date.accessioned | 2009-12-24T11:13:46Z | - |
dc.date.available | 2009-12-24T11:13:46Z | - |
dc.date.issued | 2005-07-09 | - |
dc.identifier.citation | Respir Res. 2005 Jul 7;6:67. | en |
dc.identifier.issn | 1465-993X (Electronic) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16001979 | - |
dc.identifier.uri | https://hdl.handle.net/10371/22603 | - |
dc.description.abstract | BACKGROUND: Virus infections are the major cause of asthma exacerbations. CD8+ T cells have an important role in antiviral immune responses and animal studies suggest a role for CD8+ T cells in the pathogenesis of virus-induced asthma exacerbations. We have previously shown that the presence of IL-4 during stimulation increases the frequency of IL-5-positive cells and CD30 surface staining in CD8+ T cells from healthy, normal subjects. In this study, we investigated whether excess IL-4 during repeated TCR/CD3 stimulation of CD8+ T cells from atopic asthmatic subjects alters the balance of type 1/type 2 cytokine production in favour of the latter. METHODS: Peripheral blood CD8+ T cells from mild atopic asthmatic subjects were stimulated in vitro with anti-CD3 and IL-2 +/- excess IL-4 and the expression of activation and adhesion molecules and type 1 and type 2 cytokine production were assessed. RESULTS: Surface expression of very late antigen-4 [VLA-4] and LFA-1 was decreased and the production of the type 2 cytokines IL-5 and IL-13 was augmented by the presence of IL-4 during stimulation of CD8+ T cells from mild atopic asthmatics. CONCLUSION: These data suggest that during a respiratory virus infection activated CD8+ T cells from asthmatic subjects may produce excess type 2 cytokines and may contribute to asthma exacerbation by augmenting allergic inflammation. | en |
dc.language.iso | en | en |
dc.publisher | BioMed Central | en |
dc.subject | Adult | en |
dc.subject | Asthma/classification/*immunology/pathology | en |
dc.subject | CD8-Positive T-Lymphocytes/*immunology | en |
dc.subject | Cells, Cultured | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Integrin alpha4beta1/*immunology | en |
dc.subject | Interleukin-13/*immunology | en |
dc.subject | Interleukin-4/*immunology | en |
dc.subject | Interleukin-5/*immunology | en |
dc.subject | Lymphocyte Activation/immunology | en |
dc.subject | Lymphocyte Function-Associated Antigen-1/*immunology | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Th1 Cells/immunology | en |
dc.subject | Th2 Cells/immunology | en |
dc.title | IL-4 increases type 2, but not type 1, cytokine production in CD8+ T cells from mild atopic asthmatics | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 조상헌 | - |
dc.identifier.doi | 10.1186/1465-9921-6-67 | - |
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