Publications
Detailed Information
IL-4 increases type 2, but not type 1, cytokine production in CD8+ T cells from mild atopic asthmatics
Cited 12 time in
Web of Science
Cited 9 time in Scopus
- Authors
- Issue Date
- 2005-07-09
- Publisher
- BioMed Central
- Citation
- Respir Res. 2005 Jul 7;6:67.
- Keywords
- Adult ; Asthma/classification/*immunology/pathology ; CD8-Positive T-Lymphocytes/*immunology ; Cells, Cultured ; Female ; Humans ; Integrin alpha4beta1/*immunology ; Interleukin-13/*immunology ; Interleukin-4/*immunology ; Interleukin-5/*immunology ; Lymphocyte Activation/immunology ; Lymphocyte Function-Associated Antigen-1/*immunology ; Male ; Middle Aged ; Th1 Cells/immunology ; Th2 Cells/immunology
- Abstract
- BACKGROUND: Virus infections are the major cause of asthma exacerbations. CD8+ T cells have an important role in antiviral immune responses and animal studies suggest a role for CD8+ T cells in the pathogenesis of virus-induced asthma exacerbations. We have previously shown that the presence of IL-4 during stimulation increases the frequency of IL-5-positive cells and CD30 surface staining in CD8+ T cells from healthy, normal subjects. In this study, we investigated whether excess IL-4 during repeated TCR/CD3 stimulation of CD8+ T cells from atopic asthmatic subjects alters the balance of type 1/type 2 cytokine production in favour of the latter. METHODS: Peripheral blood CD8+ T cells from mild atopic asthmatic subjects were stimulated in vitro with anti-CD3 and IL-2 +/- excess IL-4 and the expression of activation and adhesion molecules and type 1 and type 2 cytokine production were assessed. RESULTS: Surface expression of very late antigen-4 [VLA-4] and LFA-1 was decreased and the production of the type 2 cytokines IL-5 and IL-13 was augmented by the presence of IL-4 during stimulation of CD8+ T cells from mild atopic asthmatics. CONCLUSION: These data suggest that during a respiratory virus infection activated CD8+ T cells from asthmatic subjects may produce excess type 2 cytokines and may contribute to asthma exacerbation by augmenting allergic inflammation.
- ISSN
- 1465-993X (Electronic)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16001979
https://hdl.handle.net/10371/22603
- Files in This Item:
- Appears in Collections:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.