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The effect of tiarellic acid on the expressions of matrix metalloproteinase-1 and type 1 procollagen in ultraviolet irradiated cultured human skin fibroblasts

Cited 8 time in Web of Science Cited 6 time in Scopus
Authors
Moon, H. I.; Lee, J.; Eun, H. C.; Kim, K. H.; Chung, J. H.
Issue Date
2005-03-15
Publisher
Elsevier
Citation
J Ethnopharmacol. 2005 Apr 8;98(1-2):185-9.
Keywords
Catechin/analogs & derivatives/pharmacologyCells, CulturedCollagen Type I/*drug effects/genetics/radiation effectsDose-Response Relationship, DrugFibroblasts/*drug effects/radiation effectsGene Expression/drug effects/geneticsHumansMatrix Metalloproteinase 1/antagonists & inhibitors/*drugeffects/radiation effectsPlants, Medicinal/chemistrySkin/drug effects/pathology/radiation effectsTime FactorsTriterpenes/chemistry/isolation & purification/*pharmacologyUltraviolet Rays/*adverse effects
Abstract
Long term and repeated exposure of ultraviolet (UV) light, a harmful environmental stress, on the skin often induces chronic skin diseases such as skin cancer as well as photoaging (premature skin aging), and the mechanisms of these skin damages are closely associated with up-regulation of matrix metalloproteinases (MMPs) activities. Here we investigated the effect of tiarellic acid on the expressions of MMP-1 and type 1 procollagen in ultraviolet irradiation of cultured human skin fibroblasts. Tiarellic acid reduced the expression of MMP-1 and induced the expression of type 1- procollagen at the protein levels in a dose-dependent manner by ultraviolet irradiation. Taken together, our results suggest that tiarellic acid plays an important role in the reduction of MMP-1 and induction of type 1- procollagen by ultraviolet irradiation.
ISSN
0378-8741 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15763381

http://hdl.handle.net/10371/22614
DOI
https://doi.org/10.1016/j.jep.2005.01.027
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College of Medicine/School of Medicine (의과대학/대학원)Immunology (면역학전공)Journal Papers (저널논문_면역학전공)
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