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Bis-styrylpyridine and bis-styrylbenzene derivatives as inhibitors for Abeta fibril formation

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dc.contributor.authorByeon, Seong Rim-
dc.contributor.authorLee, Ji Hoon-
dc.contributor.authorSohn, Ji-Hoon-
dc.contributor.authorKim, Dong Chan-
dc.contributor.authorShin, Kye Jung-
dc.contributor.authorYoo, Kyung Ho-
dc.contributor.authorMook-Jung, Inhee-
dc.contributor.authorLee, Won Koo-
dc.contributor.authorKim, Dong Jin-
dc.date.accessioned2009-12-28T06:17:53Z-
dc.date.available2009-12-28T06:17:53Z-
dc.date.issued2007-02-03-
dc.identifier.citationBioorg Med Chem Lett. 2007 Mar 1;17(5):1466-70. Epub 2006 Nov 2.en
dc.identifier.issn0960-894X (Print)-
dc.identifier.urihttp://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TF9-4M81C09-5&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=0766e824064330fa3ec9090b1988c661-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17270435-
dc.identifier.urihttps://hdl.handle.net/10371/22852-
dc.description.abstractNew bis-styrylpyridine and bis-styrylbenzene derivatives were designed and synthesized. These 34 compounds were evaluated by Abeta fibril formation inhibitory assay using thioflavin T as a dye (named ThT assay). Most of them showed excellent inhibitory activities for Abeta fibril formation at IC50 of 0.1-2.7 microM which is comparable to curcumin (IC50 of 0.8 microM). Among them, nine compounds were screened for their cytotoxicities on HT-22 cell by MTT assay at 1, 10, and 50 microM. In particular, I-7 and II-2 exhibited the best combination of inhibitory activity and compound cytotoxicity.en
dc.language.isoenen
dc.publisherElsevieren
dc.subjectAmyloid beta-Protein/*antagonists & inhibitorsen
dc.subjectAnimalsen
dc.subjectBenzene Derivatives/*chemical synthesis/*pharmacologyen
dc.subjectCell Lineen
dc.subjectCell Survival/drug effectsen
dc.subjectDrug Designen
dc.subjectInhibitory Concentration 50en
dc.subjectMiceen
dc.subjectPyridines/chemical synthesis/pharmacologyen
dc.subjectStructure-Activity Relationshipen
dc.subjectStyrenes/chemical synthesis/pharmacologyen
dc.subjectThiazolesen
dc.titleBis-styrylpyridine and bis-styrylbenzene derivatives as inhibitors for Abeta fibril formationen
dc.typeArticleen
dc.contributor.AlternativeAuthor이지훈-
dc.contributor.AlternativeAuthor손지훈-
dc.contributor.AlternativeAuthor김동찬-
dc.contributor.AlternativeAuthor신계정-
dc.contributor.AlternativeAuthor유경호-
dc.contributor.AlternativeAuthor이원구-
dc.contributor.AlternativeAuthor김동진-
dc.identifier.doi10.1016/j.bmcl.2006.10.090-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Program in Cancer Biology (협동과정-종양생물학전공)Journal Papers (저널논문_협동과정-종양생물학전공)
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