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Bis-styrylpyridine and bis-styrylbenzene derivatives as inhibitors for Abeta fibril formation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Byeon, Seong Rim | - |
dc.contributor.author | Lee, Ji Hoon | - |
dc.contributor.author | Sohn, Ji-Hoon | - |
dc.contributor.author | Kim, Dong Chan | - |
dc.contributor.author | Shin, Kye Jung | - |
dc.contributor.author | Yoo, Kyung Ho | - |
dc.contributor.author | Mook-Jung, Inhee | - |
dc.contributor.author | Lee, Won Koo | - |
dc.contributor.author | Kim, Dong Jin | - |
dc.date.accessioned | 2009-12-28T06:17:53Z | - |
dc.date.available | 2009-12-28T06:17:53Z | - |
dc.date.issued | 2007-02-03 | - |
dc.identifier.citation | Bioorg Med Chem Lett. 2007 Mar 1;17(5):1466-70. Epub 2006 Nov 2. | en |
dc.identifier.issn | 0960-894X (Print) | - |
dc.identifier.uri | http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TF9-4M81C09-5&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=0766e824064330fa3ec9090b1988c661 | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17270435 | - |
dc.identifier.uri | https://hdl.handle.net/10371/22852 | - |
dc.description.abstract | New bis-styrylpyridine and bis-styrylbenzene derivatives were designed and synthesized. These 34 compounds were evaluated by Abeta fibril formation inhibitory assay using thioflavin T as a dye (named ThT assay). Most of them showed excellent inhibitory activities for Abeta fibril formation at IC50 of 0.1-2.7 microM which is comparable to curcumin (IC50 of 0.8 microM). Among them, nine compounds were screened for their cytotoxicities on HT-22 cell by MTT assay at 1, 10, and 50 microM. In particular, I-7 and II-2 exhibited the best combination of inhibitory activity and compound cytotoxicity. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Amyloid beta-Protein/*antagonists & inhibitors | en |
dc.subject | Animals | en |
dc.subject | Benzene Derivatives/*chemical synthesis/*pharmacology | en |
dc.subject | Cell Line | en |
dc.subject | Cell Survival/drug effects | en |
dc.subject | Drug Design | en |
dc.subject | Inhibitory Concentration 50 | en |
dc.subject | Mice | en |
dc.subject | Pyridines/chemical synthesis/pharmacology | en |
dc.subject | Structure-Activity Relationship | en |
dc.subject | Styrenes/chemical synthesis/pharmacology | en |
dc.subject | Thiazoles | en |
dc.title | Bis-styrylpyridine and bis-styrylbenzene derivatives as inhibitors for Abeta fibril formation | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 이지훈 | - |
dc.contributor.AlternativeAuthor | 손지훈 | - |
dc.contributor.AlternativeAuthor | 김동찬 | - |
dc.contributor.AlternativeAuthor | 신계정 | - |
dc.contributor.AlternativeAuthor | 유경호 | - |
dc.contributor.AlternativeAuthor | 이원구 | - |
dc.contributor.AlternativeAuthor | 김동진 | - |
dc.identifier.doi | 10.1016/j.bmcl.2006.10.090 | - |
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