Publications
Detailed Information
Bis-styrylpyridine and bis-styrylbenzene derivatives as inhibitors for Abeta fibril formation
Cited 33 time in
Web of Science
Cited 35 time in Scopus
- Authors
- Issue Date
- 2007-02-03
- Publisher
- Elsevier
- Citation
- Bioorg Med Chem Lett. 2007 Mar 1;17(5):1466-70. Epub 2006 Nov 2.
- Keywords
- Amyloid beta-Protein/*antagonists & inhibitors ; Animals ; Benzene Derivatives/*chemical synthesis/*pharmacology ; Cell Line ; Cell Survival/drug effects ; Drug Design ; Inhibitory Concentration 50 ; Mice ; Pyridines/chemical synthesis/pharmacology ; Structure-Activity Relationship ; Styrenes/chemical synthesis/pharmacology ; Thiazoles
- Abstract
- New bis-styrylpyridine and bis-styrylbenzene derivatives were designed and synthesized. These 34 compounds were evaluated by Abeta fibril formation inhibitory assay using thioflavin T as a dye (named ThT assay). Most of them showed excellent inhibitory activities for Abeta fibril formation at IC50 of 0.1-2.7 microM which is comparable to curcumin (IC50 of 0.8 microM). Among them, nine compounds were screened for their cytotoxicities on HT-22 cell by MTT assay at 1, 10, and 50 microM. In particular, I-7 and II-2 exhibited the best combination of inhibitory activity and compound cytotoxicity.
- ISSN
- 0960-894X (Print)
- Language
- English
- URI
- http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TF9-4M81C09-5&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=0766e824064330fa3ec9090b1988c661
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17270435
https://hdl.handle.net/10371/22852
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.