S-Space College of Medicine/School of Medicine (의과대학/대학원) Program in Clinical Pharmacology (협동과정-임상약리학전공) Journal Papers (저널논문_협동과정-임상약리학전공)
Cortical thinning in obsessive compulsive disorder
- Shin, Yong-Wook; Yoo, So Young; Lee, Jun Ki; Ha, Tae Hyon; Lee, Kyung Jin; Lee, Jong Min; Kim, In Young; Kim, Sun I; Kwon, Jun Soo
- Issue Date
- Hum Brain Mapp. 2007 Nov;28(11):1128-35.
- Adult; Atrophy/etiology/*pathology/physiopathology; Brain Mapping; Cerebral Cortex/*pathology/physiopathology; Female; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Neurodegenerative Diseases/*pathology/physiopathology; Obsessive-Compulsive Disorder/*pathology/physiopathology; Predictive Value of Tests; Prefrontal Cortex/pathology/physiopathology; Temporal Lobe/pathology/physiopathology
- Although studies of obsessive-compulsive disorder (OCD) over the last 20 years have suggested abnormalities in frontal-subcortical circuitry, evidences of structural abnormalities in those areas are still imperfect and contradictory. With recent advances in neuroimaging technology, it is now possible to study cortical thickness based on cortical surfaces, which offers a direct quantitative index of cortical mass. Using the constrained Laplacian-based automated segmentation with proximities (CLASP) algorithm, we measured cortical thickness of 55 patients with OCD (33 men and 22 women) and 52 age- and sex-matched healthy volunteers (32 men and 20 women). We found multiple regions of cortical thinning in OCD patients compared to the normal control group. Patients with OCD had thinner left inferior frontal, left middle frontal, left precentral, left superior temporal, left parahippocampal, left orbitofrontal, and left lingual cortices. Most thinned regions were located in the left ventral cortex system, providing a new perspective that this ventral cortical system may be involved in the pathophysiology of OCD.
- 1065-9471 (Print)
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