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Immunogenicity and safety of pneumococcal 7-valent conjugate vaccine (diphtheria CRM(197) protein conjugate; Prevenar ) in Korean infants: differences that are found in Asian children

Cited 18 time in Web of Science Cited 20 time in Scopus
Authors
Kim, Nam-Hee; Lee, Jina; Lee, Sang Jeong; Lee, Hyunju; Kim, Kyung-Hyo; Park, Su-Eun; Lee, Hoan-Jong
Issue Date
2007-10-13
Publisher
Elsevier
Citation
Vaccine 2007;25(45):7858-65
Keywords
Antibody Formation/*immunologyAsiaDose-Response Relationship, ImmunologicHumansImmunizationInfantKorea/epidemiologyMeningococcal Vaccines/administration & dosage/adverse effects/*immunologyPneumococcal Vaccines/administration & dosage/adverse effects/*immunology*SafetyVaccines, Combined/adverse effects/immunologyVaccines, Conjugate/*administration & dosage/*immunology
Abstract
This study was conducted to determine the immunogenicity and safety of a 7-valent CRM197 protein conjugated pneumococcal vaccine (PCV7) in Korean infants immunized at 2, 4 and 6 months. A total of 202 infants were enrolled and 146 and 141 infants were, respectively, included in post-2nd dose and post-3rd dose immunogenicity evaluations conducted on a per protocol basis. After two and three PCV7 vaccinations, 63.0-98.0 and 97.2-100% of infants achieved an antibody level of >or=0.35microg/mL, respectively, with a lowest against serotype 6B. No vaccination-related serious adverse reactions were observed. Thus, PCV7 appears safe and highly immunogenic in Korean infants, and adopting two doses for a primary series could be a feasible option for facilitating vaccine coverage rate.
ISSN
0264-410X (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17931753

http://hdl.handle.net/10371/23423
DOI
https://doi.org/10.1016/j.vaccine.2007.08.022
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College of Medicine/School of Medicine (의과대학/대학원)Pediatrics (소아과학전공)Journal Papers (저널논문_소아과학전공)
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