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SPP1 polymorphisms associated with HBV clearance and HCC occurrence

Cited 33 time in Web of Science Cited 32 time in Scopus
Authors
Shin, Hyoung Doo; Park, Byung Lae; Cheong, Hyun Sub; Yoon, Jung-Hwan; Kim, Yoon Jun; Lee, Hyo-Suk
Issue Date
2007-05-15
Publisher
Oxford University Press
Citation
Int J Epidemiol 2007;36:1001-8
Keywords
Age of OnsetCarcinoma, Hepatocellular/*genetics/virologyChromosome MappingDisease ProgressionFemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeHaplotypesHepatitis B virus/isolation & purificationHepatitis B, Chronic/complications/*genetics/virologyHumansLiver Neoplasms/*genetics/virologyLogistic ModelsMaleMiddle AgedOsteopontin/*genetics*Polymorphism, Single NucleotideProspective Studies
Abstract
BACKGROUND: Secreted phosphoprotein-1 (SPP1) is a secreted arginine-glycine-aspartate (RGD)-containing phosphoprotein. SPP1 is overexpressed in metastatic hepatocellular carcinoma (HCC), and therefore could act as both a diagnostic marker and a potential therapeutic target for metastatic HCC. We investigated the genetic polymorphisms in SPP1 to determine whether it is a potential candidate gene for a host genetic study of hepatitis B virus (HBV) clearance and HCC occurrence. METHODS: Five genetic variants in SPP1 were genotyped by TaqMan assay and the genetic association with HBV clearance and HCC occurrence was analysed. RESULTS: Genetic association analysis of SPP1 polymorphisms with an HBV cohort (n = 1,069) from the Korean population revealed that the most common haplotype (SPP1-ht2 [T-T-C-T-A]) was associated with HBV clearance. The frequency of the SPP1-ht2-bearing genotype in the chronic carrier (CC) group was higher than in the spontaneously recovered (SR) group (OR = 1.44 [95% CI 1.11-1.87], P = 0.006, P(corr) = 0.02). By Cox relative hazard analysis, both SPP1-ht2 and -1,800G > T were associated with age of HCC occurrence among chronic hepatitis patients, e.g. ht2/h2- and 1800T/T-bearing patients showed earlier progression to HCC than did others (RH = 1.85, P = 0.004, P(corr) = 0.01 and RH = 1.85, P = 0.003, P(corr) = 0.01, respectively). CONCLUSION: Our findings suggest that SPP1 polymorphisms might be among the genetic factors for HBV clearance and/or HCC occurrence.
ISSN
0300-5771 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17496055

http://hdl.handle.net/10371/23627
DOI
https://doi.org/10.1093/ije/dym093
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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