S-Space College of Medicine/School of Medicine (의과대학/대학원) Psychiatry (정신과학전공) Journal Papers (저널논문_정신과학전공)
Transient activation of protein phosphatase 2A induced by electroconvulsive shock in the rat frontal cortex
- Kang, Ung Gu; Jeon, Won Je; Kim, Yeni; Chung, Chun Kee; Park, Joo Bae; Juhnn, Yong Sung; Kim, Yong Sik
- Issue Date
- Neurosci Lett. 2005 Dec 30;390(3):171-5. Epub 2005 Sep 6.
- Analysis of Variance; Animals; Blotting, Western/methods; Dose-Response Relationship, Radiation; Electroshock/*methods; Enzyme Activation/radiation effects; Frontal Lobe/metabolism/*radiation effects; Gene Expression Regulation/*radiation effects; Male; Phosphoprotein Phosphatases/*metabolism; Phosphorylation/radiation effects; Protein Kinases/metabolism; Protein Phosphatase 2; Rats; Rats, Sprague-Dawley; Serine/metabolism; Threonine/metabolism; Time Factors
- We have attempted to determine the effects of electroconvulsive shock (ECS) on protein phosphatase 2A (PP2A) in the frontal cortices of rats. PP2A exhibited a 30% increase in activity immediately after ECS treatment. Immunoblot analysis revealed that phosphorylation signals, including protein kinase B (Akt/PKB), glycogen synthase kinase-3beta (GSK-3beta), and cyclic adenosine monophosphate response element binding protein (CREB) were reduced immediately after ECS treatment. When an additional ECS was administered after the activation of these kinases, the immediate reactivation of PP2A overrode the kinase activity. ECS induces transient PP2A activation prior to kinase activation, and this pattern of activity may induce the biphasic phosphorylation of substrate proteins.
- 0304-3940 (Print)
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