Publications
Detailed Information
Acupuncture inhibits microglial activation and inflammatory events in the MPTP-induced mouse model
Cited 84 time in
Web of Science
Cited 90 time in Scopus
- Authors
- Issue Date
- 2006-12-19
- Publisher
- Elsevier
- Citation
- Brain Res. 2007 Feb 2;1131(1):211-9. Epub 2006 Dec 14.
- Keywords
- Acupuncture/*methods/trends ; Animals ; Biological Markers/metabolism ; Corpus Striatum/metabolism/physiopathology ; Cyclooxygenase 2/metabolism ; Cytoprotection/*physiology ; Disease Models, Animal ; Dopamine/biosynthesis ; Encephalitis/chemically induced/prevention & control/*therapy ; Gliosis/chemically induced/prevention & control/*therapy ; Macrophage-1 Antigen/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Microglia/drug effects/*physiology ; Nitric Oxide Synthase Type II/metabolism ; Parkinsonian Disorders/physiopathology/prevention & control/*therapy ; Substantia Nigra/metabolism/physiopathology ; Treatment Outcome ; Tyrosine 3-Monooxygenase/metabolism ; Up-Regulation/physiology
- Abstract
- Using a mouse model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease (PD), this study investigated on the neuroprotective effects of acupuncture by examining whether acupuncture contributed to inhibiting microglial activation and inflammatory events. C57BL/6 mice were treated with MPTP (30 mg/kg, i.p.) for 5 consecutive days. Acupuncture was then applied to acupoints Yanglingquan (GB34) and Taichong (LR3) starting 2 h after the first MPTP administration and then at 48 h intervals until the mice were sacrificed for analyses at 1, 3, and 7 days after the last MPTP injection. These experiments demonstrated that acupuncture inhibited the decreased of the tyrosine hydroxylase (TH) immunoreactivity (IR) and generated a neuroprotective effects in the striatum (ST) and the substantia nigra (SN) on days 1, 3, and 7 post-MPTP injections. Acupuncture attenuated the increase of macrophage antigen complex-1 (MAC-1), a marker of microglial activation, at 1 and 3 days and reduced the increases in cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression on days 1, 3, and 7. In MPTP group, striatal dopamine (DA) was measured by 46% at 7 days, whereas DA in the acupuncture group was 78%. On the basis of these results, we suggest that acupuncture could be used as a neuroprotective intervention for the purpose of inhibiting microglial activation and inflammatory events in PD.
- ISSN
- 0006-8993 (Print)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17173870
https://hdl.handle.net/10371/24299
- Files in This Item:
- There are no files associated with this item.
- Appears in Collections:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.