S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Biochemistry & Molecular Biology (생화학교실) Journal Papers (저널논문_생화학교실)
Association between the MLH1 gene and longevity
- Kim, Dong Jo; Yi, Sang Mi; Lee, Seung Yeon; Kang, Heun Soo; Choi, Yoon-Ho; Song, Yeong Wook; Park, Sang Chul
- Issue Date
- Springer Verlag
- Hum Genet. 2006 Apr;119(3):353-4. Epub 2006 Feb 11.
- Adaptor Proteins, Signal Transducing; Aged; Aged, 80 and over; Carrier Proteins/*genetics; Female; Gene Frequency; Genetic Screening/methods; Haplotypes; Humans; Longevity/*genetics; Male; Middle Aged; Nuclear Proteins/*genetics; Polymorphism, Single Nucleotide
- Perturbations in genomic stability result in cancer, a reduced life span, and premature aging. MLH1 is a mismatch repair enzyme that acts to maintain genomic stability, and a loss of MLH1 increases cancer incidence and apoptosis resistance, which suggests a link between MLH1 and longevity. We found here that MLH1 is associated with longevity by comparing a centenarian group with a control group. Our data indicate a critical role for MLH1 in longevity.
- 0340-6717 (Print)
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