Browse

Association between the MLH1 gene and longevity

Cited 10 time in Web of Science Cited 13 time in Scopus
Authors
Kim, Dong Jo; Yi, Sang Mi; Lee, Seung Yeon; Kang, Heun Soo; Choi, Yoon-Ho; Song, Yeong Wook; Park, Sang Chul
Issue Date
2006-02-14
Publisher
Springer Verlag
Citation
Hum Genet. 2006 Apr;119(3):353-4. Epub 2006 Feb 11.
Keywords
Adaptor Proteins, Signal TransducingAgedAged, 80 and overCarrier Proteins/*geneticsFemaleGene FrequencyGenetic Screening/methodsHaplotypesHumansLongevity/*geneticsMaleMiddle AgedNuclear Proteins/*geneticsPolymorphism, Single Nucleotide
Abstract
Perturbations in genomic stability result in cancer, a reduced life span, and premature aging. MLH1 is a mismatch repair enzyme that acts to maintain genomic stability, and a loss of MLH1 increases cancer incidence and apoptosis resistance, which suggests a link between MLH1 and longevity. We found here that MLH1 is associated with longevity by comparing a centenarian group with a control group. Our data indicate a critical role for MLH1 in longevity.
ISSN
0340-6717 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16474933

https://hdl.handle.net/10371/24325
DOI
https://doi.org/10.1007/s00439-006-0148-7
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Biochemistry & Molecular Biology (생화학교실)Journal Papers (저널논문_생화학교실)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse