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Genetic variability of the fusion protein and circulation patterns of genotypes of the respiratory syncytial virus

Cited 12 time in Web of Science Cited 14 time in Scopus
Authors
Kim, Yun-Kyung; Choi, Eun-Hwa; Lee, Hoan-Jong
Issue Date
2007-04-26
Publisher
Wiley-Blackwell
Citation
J Med Virol. 2007 Jun;79(6):820-8.
Keywords
AdolescentAmino Acid SubstitutionChildChild, PreschoolEvolution, Molecular*Genetic VariationGenotypeHumansKorea/epidemiologyMutationPhylogenyRNA, Viral/geneticsRespiratory Syncytial Virus Infections/epidemiology/*virologyRespiratory Syncytial Viruses/*classification/*genetics/isolation &purificationSequence Analysis, DNASequence HomologyViral Fusion Proteins/*genetics
Abstract
Although antigenic and genetic variations were shown to occur both in the G and F protein of respiratory syncytial virus (RSV), few studies looked at the variation of F gene. The F genotypes were determined by the evaluation of clustering patterns, via the phylogenetic analysis of the nucleotide sequences of a variable region in the F gene. One hundred seventy-nine strains obtained from a children's hospital in Korea over nine consecutive epidemics were included. The relationship between the F and G genotypes was analyzed with the G genotypes previously published by the authors. The phylogenetic analysis of the variable region from the F gene revealed 9 genotypes among 129 group A RSVs and 4 genotypes among 50 group B RSVs. In each of the epidemics, the dominant genotypes were replaced with new genotypes in consecutive epidemics. In each of the epidemics of group B RSVs, the predominant genotype alternated between genotypes. Most of the strains which clustered to a particular F genotype were assigned to particular G genotype(s). By determining the nearly entire sequences of the F genes, we revealed the percentage of the nucleotide differences which resulted in amino acid coding changes was determined to be much great in two distinct variable regions of the F gene. Our results indicated that the F gene of the RSVs may be continuously evolving under selective pressure in a distinct pattern, and that the genetic variability of the F protein is associated with that of the G protein.
ISSN
0146-6615 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17457915

https://hdl.handle.net/10371/24380
DOI
https://doi.org/10.1002/jmv.20891
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Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Pediatrics (소아과학전공)Journal Papers (저널논문_소아과학전공)
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