Browse

Quantitative analysis of group-specific brain tissue probability map for schizophrenic patients

Cited 7 time in Web of Science Cited 8 time in Scopus
Authors
Yoon, Uicheul; Lee, Jong-Min; Shin, Yong-Wook; Lee, Kyung Jin; Kim, In Young; Kwon, Jun Soo; Kim, Sun I
Issue Date
2005-05-24
Publisher
Elsevier
Citation
Neuroimage. 2005 Jun;26(2):502-12. Epub 2005 Apr 7.
Keywords
AdultBrain/*pathologyBrain MappingFemaleHumansImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMaleModels, StatisticalProbabilitySchizophrenia/*pathologySex Characteristics
Abstract
We developed group-specific tissue probability map (TPM) for gray matter (GM), white matter (WM) and cerebrospinal fluid (CSF) on the common spatial coordinates of an averaged brain atlas derived from normal controls (NC) and from schizophrenic patients (SZ). To identify differences in group-specific TPMs, we used quantitative evaluation methods based on differences in probabilistic distribution as a global criterion, and the mean probability and the similarity index (SI) by lobe as regional criteria. The SZ group showed more spatial variation with a lower mean probability than NC subjects. And, for the right temporal and left parietal lobes, the SI between each group was lower than the other lobes. It can be said that there were significant differences in spatial distribution between controls and schizophrenic patients at those areas. In case of female group, although group differences in the volumes of GM and WM were not significant, global difference in the probabilistic distribution of GM was more prominent and the SI was lower and its descent rate was greater in all lobes, compared with the male group. If these morphological differences caused by disease or group-specific features were not considered in TPM, the accuracy and certainty of specific group studies would be greatly reduced. Therefore, suitable TPM is required as a common framework for functional neuroimaging studies and an a priori knowledge of tissue classification.
ISSN
1053-8119 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15907307

https://hdl.handle.net/10371/25960
DOI
https://doi.org/10.1016/j.neuroimage.2005.01.056
Files in This Item:
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse