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Prefrontal and temporal gray matter density decreases in opiate dependence
Cited 129 time in
Web of Science
Cited 148 time in Scopus
- Authors
- Issue Date
- 2005-12-22
- Publisher
- Springer Verlag
- Citation
- Psychopharmacology (Berl). 2006 Jan;184(2):139-44. Epub 2005 Dec 21.
- Keywords
- Adult ; Axons/physiology ; Female ; Humans ; Image Interpretation, Computer-Assisted ; Magnetic Resonance Imaging ; Male ; Opioid-Related Disorders/cerebrospinal fluid/*pathology ; Prefrontal Cortex/*pathology ; Psychiatric Status Rating Scales ; Temporal Lobe/*pathology
- Abstract
- RATIONALE: There have been only a few structural brain-imaging studies, with varied findings, of opiate-dependent subjects. Voxel-based morphometry (VBM) is suitable for studying whole brain-wise structural brain changes in opiate-dependent subjects. OBJECTIVES: The objective of the current study is to explore gray matter density in opiate-dependent subjects. METHODS: Gray matter density in 63 opiate-dependent subjects and 46 age- and sex-matched healthy comparison subjects was compared using VBM. RESULTS: Relative to healthy comparison subjects, opiate-dependent subjects exhibited decreased gray matter density in bilateral prefrontal cortex [Brodmann areas (BA) 8, 9, 10, 11, and 47], bilateral insula (BA 13), bilateral superior temporal cortex (BA 21 and 38), left fusiform cortex (BA 37), and right uncus (BA 28). CONCLUSIONS: This study reports that opiate-dependent subjects have gray matter density decreases in prefrontal and temporal cortex, which may be associated with behavioral and neuropsychological dysfunction in opiate-dependent subjects.
- ISSN
- 0033-3158 (Print)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16369836
https://hdl.handle.net/10371/26841
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