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Prefrontal and temporal gray matter density decreases in opiate dependence

Cited 115 time in Web of Science Cited 132 time in Scopus
Authors
Lyoo, In Kyoon; Pollack, Mark H; Silveri, Marisa M; Ahn, Kyung Heup; Diaz, Claudia I; Hwang, Jaeuk; Kim, Seog Ju; Yurgelun-Todd, Deborah A; Kaufman, Marc J; Renshaw, Perry F
Issue Date
2005-12-22
Publisher
Springer Verlag
Citation
Psychopharmacology (Berl). 2006 Jan;184(2):139-44. Epub 2005 Dec 21.
Keywords
AdultAxons/physiologyFemaleHumansImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMaleOpioid-Related Disorders/cerebrospinal fluid/*pathologyPrefrontal Cortex/*pathologyPsychiatric Status Rating ScalesTemporal Lobe/*pathology
Abstract
RATIONALE: There have been only a few structural brain-imaging studies, with varied findings, of opiate-dependent subjects. Voxel-based morphometry (VBM) is suitable for studying whole brain-wise structural brain changes in opiate-dependent subjects. OBJECTIVES: The objective of the current study is to explore gray matter density in opiate-dependent subjects. METHODS: Gray matter density in 63 opiate-dependent subjects and 46 age- and sex-matched healthy comparison subjects was compared using VBM. RESULTS: Relative to healthy comparison subjects, opiate-dependent subjects exhibited decreased gray matter density in bilateral prefrontal cortex [Brodmann areas (BA) 8, 9, 10, 11, and 47], bilateral insula (BA 13), bilateral superior temporal cortex (BA 21 and 38), left fusiform cortex (BA 37), and right uncus (BA 28). CONCLUSIONS: This study reports that opiate-dependent subjects have gray matter density decreases in prefrontal and temporal cortex, which may be associated with behavioral and neuropsychological dysfunction in opiate-dependent subjects.
ISSN
0033-3158 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16369836

https://hdl.handle.net/10371/26841
DOI
https://doi.org/10.1007/s00213-005-0198-x
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College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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