S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Physiology (생리학교실) Journal Papers (저널논문_생리학교실)
Group I mGluR regulates the polarity of spike-timing dependent plasticity in substantia gelatinosa neurons
- Jung, Sung Jun; Kim, Sang Jeong; Park, Yun Kyung; Oh, Seog Bae; Cho, Kwangwook; Kim, Jun
- Issue Date
- Biochem Biophys Res Commun. 2006 Aug 25;347(2):509-16. Epub 2006 Jun 30.
- 2-Amino-5-phosphonovalerate/pharmacology; Animals; Boron Compounds/pharmacology; Calcium/antagonists & inhibitors/metabolism; Calcium Channels; Chelating Agents/pharmacology; Egtazic Acid/analogs & derivatives/pharmacology; Estrenes/pharmacology; Excitatory Amino Acid Antagonists/pharmacology; Female; Indans/pharmacology; Inositol 1,4,5-Trisphosphate Receptors; Long-Term Potentiation/drug effects/physiology; Long-Term Synaptic Depression/drug effects/physiology; Male; Neuronal Plasticity/drug effects/*physiology; Neurons/drug effects/*physiology; Pyrrolidinones/pharmacology; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear/antagonists & inhibitors; Receptors, Metabotropic Glutamate/antagonists & inhibitors/*physiology; Staurosporine/pharmacology; Substantia Gelatinosa/cytology/drug effects/*physiology; Synaptic Transmission/drug effects/*physiology; Time Factors; Type C Phospholipases/antagonists & inhibitors
- The spinal synaptic plasticity is associated with a central sensitization of nociceptive input, which accounts for the generation of hyperalgesia in chronic pain. However, how group I metabotropic glutamate receptors (mGluRs) may operate spinal plasticity remains essentially unexplored. Here, we have identified spike-timing dependent synaptic plasticity in substantia gelatinosa (SG) neurons, using perforated patch-clamp recordings of SG neuron in a spinal cord slice preparation. In the presence of bicuculline and strychnine, long-term potentiation (LTP) was blocked by AP-5 and Ca2+ chelator BAPTA-AM. The group I mGluR antagonist AIDA, PLC inhibitor U-73122, and IP3 receptor blocker 2-APB shifted LTP to long-term depression (LTD) without affecting acute synaptic transmission. These findings provide a link between postsynaptic group I mGluR/PLC/IP3-gated Ca2+ store regulating the polarity of synaptic plasticity and spinal central sensitization.
- 0006-291X (Print)
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