S-Space College of Medicine/School of Medicine (의과대학/대학원) Internal Medicine (내과학전공) Journal Papers (저널논문_내과학전공)
IGF2 polymorphisms are associated with hepatitis B virus clearance and hepatocellular carcinoma
- Kim, Yoon Jun; Yoon, Jung-Hwan; Kim, Chung Yong; Kim, Lyoung Hyo; Park, Byung Lae; Shin, Hyoung Doo; Lee, Hyo-Suk
- Issue Date
- Biochem Biophys Res Commun. 2006 Jul 21;346(1):38-44. Epub 2006 May 24.
- Adult; Age Factors; Aged; Asian Continental Ancestry Group/genetics; Carcinoma, Hepatocellular/etiology/*genetics; Female; Haplotypes; Hepatitis B virus/immunology; Hepatitis B, Chronic/genetics/*virology; Humans; Insulin-Like Growth Factor II; Korea; Male; Middle Aged; Polymorphism, Genetic/*genetics; Polymorphism, Single Nucleotide; Prospective Studies; Proteins/*genetics
- The aim of this study was to determine whether IGF2 polymorphisms are associated with the clearance of hepatitis B virus (HBV) infection and the risk of hepatocellular carcinoma (HCC). A total of 1095 Korean subjects were prospectively enrolled in this case-control study. The rates of IGF2 polymorphisms were determined in each group. The IGF2+820G allele (IGF2+820G/G) and the IGF2+6815A/A genotype were strongly associated with the resolution of HBV infection (OR=0.62-0.73; P=0.001-0.03 and OR=0.71; P=0.03, respectively). Haplotype analysis showed that IGF2-haplotype5 (A-C-C-T-A-T-G) and IGF2-haplotype1 (T-C-T-T-A-C-A) were significantly associated with the clearance and persistence of HBV infection (OR=0.55-0.58, P=0.009-0.01 and OR=1.31-1.65, P=0.001-0.007, respectively). On the other hand, the IGF2+2482C/C or +820G/G genotypes were significantly associated with a higher risk of HCC (OR=1.88, 1.68; P=0.04). IGF2 polymorphisms were found to be strongly associated with the clearance of HBV or the occurrence of HCC in patients with chronic HBV infection.
- 0006-291X (Print)
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