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Fractal dimension of cerebral cortical surface in schizophrenia and obsessive-compulsive disorder

Cited 62 time in Web of Science Cited 62 time in Scopus
Authors
Ha, Tae Hyon; Yoon, Uicheul; Lee, Kyung Jin; Shin, Yong Wook; Lee, Jong-Min; Kim, In Young; Ha, Kyoo Seob; Kim, Sun I; Kwon, Jun Soo
Issue Date
2005-05-17
Publisher
Elsevier
Citation
Neurosci Lett. 2005 Aug 12-19;384(1-2):172-6.
Keywords
AdultCerebral Cortex/*pathologyFemaleHumansImage Interpretation, Computer-Assisted/methodsImaging, Three-Dimensional/*methodsLogistic ModelsMagnetic Resonance Imaging/methodsMaleObsessive-Compulsive Disorder/cerebrospinal fluid/*pathologySchizophrenia/cerebrospinal fluid/*pathology
Abstract
Schizophrenia and obsessive-compulsive disorder (OCD) are assumed to be neurodevelopmental disorders. To examine the cortical patterns in the two disorders, three-dimensional fractal dimension (FD) of skeletonized cerebral cortical surface was estimated from magnetic resonance (MR) images of 50 patients with schizophrenia, 45 patients with OCD and 26 healthy normal controls. The schizophrenic group had a significantly smaller mean FD than OCD group, and the OCD group than normal controls. The FD revealed a significant interaction effect of group-by-hemisphere, and the FD asymmetry index distinguished the schizophrenic group from normal controls. In logistic regression models, the FD and CSF volume correctly classified 95.6% of the schizophrenics from the controls and 88.0% of the patients with OCD from the controls. In the control and schizophrenic groups, the FD was not associated with any of tissue volume measures. In the OCD group, however, the FD was significantly correlated with gray matter tissue volume and intracranial volume (ICV). The results of the present study suggest that three-dimensional FD of cortical surface may be a sensitive indicator for investigation of the structural brain abnormalities in mental disorders, especially those developmentally disturbed. Further studies to explore regional FD changes in mental disorders and clinical implications of the FD including diagnostic value should be performed in the future.
ISSN
0304-3940 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15893428

http://hdl.handle.net/10371/27587
DOI
https://doi.org/10.1016/j.neulet.2005.04.078
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College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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