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Histone chaperones regulate histone exchange during transcription

Cited 42 time in Web of Science Cited 43 time in Scopus
Authors
Kim, Hye-Jin; Seol, Ja-Hwan; Han, Jeung-Whan; Youn, Hong-Duk; Cho, Eun-Jung
Issue Date
2007-10-05
Publisher
Nature Publishing Group
Citation
EMBO J. 2007 Oct 31;26(21):4467-74. Epub 2007 Oct 4.
Keywords
Cell Cycle Proteins/chemistryFungal Proteins/metabolismGene DeletionGene SilencingHistones/chemistry/*metabolismMolecular Chaperones/*metabolismMutationNuclear Proteins/metabolismNucleosomes/metabolismRNA Polymerase II/metabolismRepressor Proteins/metabolismSaccharomyces cerevisiae/metabolismSaccharomyces cerevisiae Proteins/chemistry/metabolismTranscription, Genetic
Abstract
Transcription by RNA polymerase II is accompanied by dynamic changes in chromatin, including the eviction/deposition of nucleosomes or the covalent modification of histone subunits. This study examined the role of the histone H3/H4 chaperones, Asf1 and HIR, in histone mobility during transcription, with particular focus on the histone exchange pathway, using a dual histone expression system. The results showed that the exchange of H3/H4 normally occurs during transcription by the histone chaperones. Both Asf1 and HIR are important for histone deposition but have a different effect on histone exchange. While Asf1 mediated incorporation of external H3/H4 and renewal of pre-existing histones, HIR opposed it. The balance of two opposing activities might be an important mechanism for determining current chromatin states.
ISSN
1460-2075 (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17914459

http://hdl.handle.net/10371/27835
DOI
https://doi.org/10.1038/sj.emboj.7601870
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College of Medicine/School of Medicine (의과대학/대학원)Program in Cancer Biology (협동과정-종양생물학전공)Journal Papers (저널논문_협동과정-종양생물학전공)
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