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Histone chaperones regulate histone exchange during transcription
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hye-Jin | - |
dc.contributor.author | Seol, Ja-Hwan | - |
dc.contributor.author | Han, Jeung-Whan | - |
dc.contributor.author | Youn, Hong-Duk | - |
dc.contributor.author | Cho, Eun-Jung | - |
dc.date.accessioned | 2010-01-07T02:10:15Z | - |
dc.date.available | 2010-01-07T02:10:15Z | - |
dc.date.issued | 2007-10-05 | - |
dc.identifier.citation | EMBO J. 2007 Oct 31;26(21):4467-74. Epub 2007 Oct 4. | en |
dc.identifier.issn | 1460-2075 (Electronic) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17914459 | - |
dc.identifier.uri | https://hdl.handle.net/10371/27835 | - |
dc.description.abstract | Transcription by RNA polymerase II is accompanied by dynamic changes in chromatin, including the eviction/deposition of nucleosomes or the covalent modification of histone subunits. This study examined the role of the histone H3/H4 chaperones, Asf1 and HIR, in histone mobility during transcription, with particular focus on the histone exchange pathway, using a dual histone expression system. The results showed that the exchange of H3/H4 normally occurs during transcription by the histone chaperones. Both Asf1 and HIR are important for histone deposition but have a different effect on histone exchange. While Asf1 mediated incorporation of external H3/H4 and renewal of pre-existing histones, HIR opposed it. The balance of two opposing activities might be an important mechanism for determining current chromatin states. | en |
dc.language.iso | en | en |
dc.publisher | Nature Publishing Group | en |
dc.subject | Cell Cycle Proteins/chemistry | en |
dc.subject | Fungal Proteins/metabolism | en |
dc.subject | Gene Deletion | en |
dc.subject | Gene Silencing | en |
dc.subject | Histones/chemistry/*metabolism | en |
dc.subject | Molecular Chaperones/*metabolism | en |
dc.subject | Mutation | en |
dc.subject | Nuclear Proteins/metabolism | en |
dc.subject | Nucleosomes/metabolism | en |
dc.subject | RNA Polymerase II/metabolism | en |
dc.subject | Repressor Proteins/metabolism | en |
dc.subject | Saccharomyces cerevisiae/metabolism | en |
dc.subject | Saccharomyces cerevisiae Proteins/chemistry/metabolism | en |
dc.subject | Transcription, Genetic | en |
dc.title | Histone chaperones regulate histone exchange during transcription | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김혜진 | - |
dc.contributor.AlternativeAuthor | 설자환 | - |
dc.contributor.AlternativeAuthor | 한정환 | - |
dc.contributor.AlternativeAuthor | 윤홍덕 | - |
dc.contributor.AlternativeAuthor | 조은정 | - |
dc.identifier.doi | 10.1038/sj.emboj.7601870 | - |
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