S-Space College of Medicine/School of Medicine (의과대학/대학원) Internal Medicine (내과학전공) Journal Papers (저널논문_내과학전공)
The effects of genetic polymorphisms of IL-1 and TNF-A on Helicobacter pylori-induced gastroduodenal diseases in Korea
- Kim, Nayoung; Cho, Sung-Il; Yim, Jeong-Yoon; Kim, Jung Mogg; Lee, Dong Ho; Park, Ji Hyun; Kim, Joo Sung; Jung, Hyun Chae; Song, In Sung
- Issue Date
- Helicobacter. 2006 Apr;11(2):105-12.
- Adult; Aged; Duodenal Ulcer/genetics/microbiology; Female; Gastrointestinal Diseases/*genetics/microbiology; Gene Frequency; Genetic Predisposition to Disease; Genotype; Helicobacter Infections/*complications; Humans; Interleukin-1/*genetics; Korea; Male; Middle Aged; Polymerase Chain Reaction; *Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Stomach Neoplasms/genetics/microbiology; Stomach Ulcer/genetics/microbiology; Tumor Necrosis Factor-alpha/*genetics
- OBJECTIVE: To evaluate whether or not genetic polymorphism of IL-1B, IL-1RN, and TNF-Alpha is an important factor in the different expression of gastroduodenal diseases after Helicobacter pylori infection. METHODS: This study consisted of 1360 subjects: control, gastric cancer (GC, intestinal type, and diffuse type), benign gastric ulcer (BGU), duodenal ulcer, and first-degree gastric cancer relative (GCR). IL-1Beta-511 and TNF-A-308 biallelic polymorphism were genotyped by 5' nuclease polymerase chain reaction (PCR) assays, and PCR-restriction fragment length polymorphism (PCR-RFLP). IL-1RN penta-allelic variable number of tandem repeats was genotyped by PCR. RESULTS: There was no difference in the genetic polymorphism of IL-1Beta-511, IL-1RN and TNF-A in the patients with gastric cancer regardless of H. pylori positivity compared with control. However, the frequencies of IL-1B-511 C/T (OR: 0.5, 95% CI: 0.3-0.7) and T carrier (OR: 0.6, 95% CI: 0.4-0.8) were lower in the H. pylori-positive BGU patients. The IL-1RN 2/2 was higher (OR: 5.5, 95% CI: 1.1-28.5) in the H. pylori-positive GCR. There was no significance in the polymorphism of TNF-Alpha-308 regardless of H. pylori-induced gastroduodenal diseases. CONCLUSIONS: The IL-1Beta-511 T-carrier polymorphism has a negative effect on the development of H. pylori-positive BGU, and high frequency of IL-1RN 2/2 was found in the H. pylori-positive relatives of GC patients, which suggest that this genetic polymorphism could play some role in the H. pylori-induced gastroduodenal diseases in Korea.
- 1083-4389 (Print)
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