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High fluorodeoxyglucose uptake on positron emission tomography in patients with advanced non-small cell lung cancer on platinum-based combination chemotherapy

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dc.contributor.authorLee, Kyung-Hun-
dc.contributor.authorLee, Se-Hoon-
dc.contributor.authorKim, Dong-Wan-
dc.contributor.authorKang, Won Jun-
dc.contributor.authorChung, June-Key-
dc.contributor.authorIm, Seock-Ah-
dc.contributor.authorKim, Tae-You-
dc.contributor.authorKim, Young Whan-
dc.contributor.authorBang, Yung-Jue-
dc.contributor.authorHeo, Dae Seog]-
dc.date.accessioned2010-01-07T06:33:04Z-
dc.date.available2010-01-07T06:33:04Z-
dc.date.issued2006-07-
dc.identifier.citationClinical Cancer Research, Vol.12 No.14, pp.4232-4236-
dc.identifier.issn1078-0432-
dc.identifier.other95298-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16857796-
dc.identifier.urihttps://hdl.handle.net/10371/28463-
dc.description.abstractPurpose: To evaluate response and survival for platinum-based combination chemotherapy in chemonaive patients with non - small cell lung cancer (NSCLC) according to pretreatment standardized uptake values (SUV) by fluorodeoxyglucose positron emission tomography. Experimental Design: Patients with advanced NSCLC who had not previously received chemotherapy were eligible. Response rates and survivals were analyzed according to maximal SUVs [low (<= 7.5) versus high (>7.5), where 7.5 was the median value] before the first cycle of chemotherapy. Results: Eighty-five consecutive patients were included in the retrospective study. Patients with high SUV tumors exhibited significantly higher response rates (34.1% for low SUVs versus 61.0% for high SUVs; P = 0.013). Other factors, including sex, age, histology, performance status, number of involved organs, regimens used, and disease stage, did not affect response. However, high SUVs were related with a shorter response duration (279 days for low SUVs versus 141 days for high SUVs; P = 0.003) and time to progression (282 days for low SUVs versus 169 days for high SUVs; P = 0.015). Overall survival was unaffected by maximal SUVs (623 days for low SUVs versus 464 days for high SUVs; P = 0.431). Conclusions: Patients having NSCLC with high maximal SUVs showed a better response to platinum-based combination chemotherapy but had a shorter time to progression. Tumor glucose metabolism, as determined by SUVs on fluorodeoxyglucose positron emission tomography, was found to discriminate NSCLC subsets with different clinical and biological features.-
dc.language.isoen-
dc.publisherAmerican Association for Cancer Researchen
dc.subjectAgeden
dc.subjectAntineoplastic Combined Chemotherapy Protocols/*therapeutic useen
dc.subjectCarcinoma, Non-Small-Cell Lung/*diagnosis/*radionuclide imagingen
dc.subjectCisplatin/*administration & dosageen
dc.subjectFemaleen
dc.subjectFluorodeoxyglucose F18/*pharmacokineticsen
dc.subjectHumansen
dc.subjectLung Neoplasms/*diagnosis/*radionuclide imagingen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectPositron-Emission Tomography/*methodsen
dc.subjectRadiopharmaceuticals/*diagnostic useen
dc.subjectRetrospective Studiesen
dc.subjectTime Factorsen
dc.subjectTreatment Outcomeen
dc.titleHigh fluorodeoxyglucose uptake on positron emission tomography in patients with advanced non-small cell lung cancer on platinum-based combination chemotherapy-
dc.typeArticle-
dc.contributor.AlternativeAuthor임석아-
dc.identifier.doi10.1158/1078-0432.CCR-05-2710-
dc.citation.journaltitleClinical Cancer Research-
dc.identifier.scopusid2-s2.0-34250689001-
dc.citation.endpage4236-
dc.citation.number14-
dc.citation.startpage4232-
dc.citation.volume12-
dc.identifier.urlhttps://clincancerres.aacrjournals.org/content/12/14/4232-
dc.identifier.rimsid95298-
dc.identifier.sci000239373200016-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorKim, Dong-Wan-
dc.contributor.affiliatedAuthorIm, Seock-Ah-
dc.contributor.affiliatedAuthorBang, Yung-Jue-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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