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High fluorodeoxyglucose uptake on positron emission tomography in patients with advanced non-small cell lung cancer on platinum-based combination chemotherapy
DC Field | Value | Language |
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dc.contributor.author | Lee, Kyung-Hun | - |
dc.contributor.author | Lee, Se-Hoon | - |
dc.contributor.author | Kim, Dong-Wan | - |
dc.contributor.author | Kang, Won Jun | - |
dc.contributor.author | Chung, June-Key | - |
dc.contributor.author | Im, Seock-Ah | - |
dc.contributor.author | Kim, Tae-You | - |
dc.contributor.author | Kim, Young Whan | - |
dc.contributor.author | Bang, Yung-Jue | - |
dc.contributor.author | Heo, Dae Seog | - |
dc.date.accessioned | 2010-01-07T06:33:04Z | - |
dc.date.available | 2010-01-07T06:33:04Z | - |
dc.date.created | 2020-04-08 | - |
dc.date.created | 2020-04-08 | - |
dc.date.issued | 2006-07-15 | - |
dc.identifier.citation | Clinical Cancer Research, Vol.12 No.14, pp.4232-4236 | - |
dc.identifier.issn | 1078-0432 | - |
dc.identifier.other | 95298 | - |
dc.identifier.uri | https://hdl.handle.net/10371/28463 | - |
dc.description.abstract | Purpose: To evaluate response and survival for platinum-based combination chemotherapy in chemonaive patients with non - small cell lung cancer (NSCLC) according to pretreatment standardized uptake values (SUV) by fluorodeoxyglucose positron emission tomography. Experimental Design: Patients with advanced NSCLC who had not previously received chemotherapy were eligible. Response rates and survivals were analyzed according to maximal SUVs [low (<= 7.5) versus high (>7.5), where 7.5 was the median value] before the first cycle of chemotherapy. Results: Eighty-five consecutive patients were included in the retrospective study. Patients with high SUV tumors exhibited significantly higher response rates (34.1% for low SUVs versus 61.0% for high SUVs; P = 0.013). Other factors, including sex, age, histology, performance status, number of involved organs, regimens used, and disease stage, did not affect response. However, high SUVs were related with a shorter response duration (279 days for low SUVs versus 141 days for high SUVs; P = 0.003) and time to progression (282 days for low SUVs versus 169 days for high SUVs; P = 0.015). Overall survival was unaffected by maximal SUVs (623 days for low SUVs versus 464 days for high SUVs; P = 0.431). Conclusions: Patients having NSCLC with high maximal SUVs showed a better response to platinum-based combination chemotherapy but had a shorter time to progression. Tumor glucose metabolism, as determined by SUVs on fluorodeoxyglucose positron emission tomography, was found to discriminate NSCLC subsets with different clinical and biological features. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | American Association for Cancer Research | - |
dc.title | High fluorodeoxyglucose uptake on positron emission tomography in patients with advanced non-small cell lung cancer on platinum-based combination chemotherapy | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 임석아 | - |
dc.identifier.doi | 10.1158/1078-0432.CCR-05-2710 | - |
dc.citation.journaltitle | Clinical Cancer Research | - |
dc.identifier.wosid | 000239373200016 | - |
dc.identifier.scopusid | 2-s2.0-34250689001 | - |
dc.citation.endpage | 4236 | - |
dc.citation.number | 14 | - |
dc.citation.startpage | 4232 | - |
dc.citation.volume | 12 | - |
dc.identifier.sci | 000239373200016 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Kim, Dong-Wan | - |
dc.contributor.affiliatedAuthor | Chung, June-Key | - |
dc.contributor.affiliatedAuthor | Im, Seock-Ah | - |
dc.contributor.affiliatedAuthor | Kim, Tae-You | - |
dc.contributor.affiliatedAuthor | Kim, Young Whan | - |
dc.contributor.affiliatedAuthor | Bang, Yung-Jue | - |
dc.contributor.affiliatedAuthor | Heo, Dae Seog | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | PREOPERATIVE CHEMOTHERAPY | - |
dc.subject.keywordPlus | NEOADJUVANT CHEMOTHERAPY | - |
dc.subject.keywordPlus | GLUCOSE-METABOLISM | - |
dc.subject.keywordPlus | PREDICTIVE MARKERS | - |
dc.subject.keywordPlus | REPRODUCIBILITY | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | FDG | - |
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