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Differential distribution of mechanosensitive nonselective cation channels in systemic and pulmonary arterial myocytes of rabbits

Cited 9 time in Web of Science Cited 9 time in Scopus
Authors
Park, Kyung Sun; Lee, Hyang Ae; Earm, Kee Hyun; Ko, Jae Hong; Earm, Yung E; Kim, Sung Joon
Issue Date
2006-05-31
Publisher
Karger
Citation
J Vasc Res. 2006;43(4):347-54. Epub 2006 May 29.
Keywords
Animals*CationsCoronary Vessels/anatomy & histology/*physiologyIon Channel GatingIon Channels/*physiologyMechanoreceptors/*physiologyMechanotransduction, CellularMembrane PotentialsMesenteric Arteries/anatomy & histology/*physiologyMuscle ContractionMyocytes, Smooth Muscle/physiologyPatch-Clamp TechniquesPressurePulmonary Artery/anatomy & histology/*physiologyRabbits
Abstract
The mechanosensitive nonselective cation channel (NSC(MS)) is a key player in vascular myogenic contraction. The functional channel density and pressure sensitivity of NSC(MS) in vascular myocytes were compared between pulmonary and systemic arteries (coronary, mesenteric and cerebral arteries) in the rabbit. In cell-attached condition, a negative pressure via patch pipettes commonly activated NSC(MS) with weak voltage dependence. The threshold pressure for activation was lower, and the density of NSC(MS) was higher in the pulmonary than the systemic arteries. When the pulmonary arteries were divided into small-diameter (outer diameter, OD < 0.5 mm) and large-diameter (OD > 1.5 mm) arteries, the low threshold and high density of NSC(MS) were observed only in small-diameter ones. No such difference was observed between the small- and large-diameter coronary arteries. The higher stretch sensitivity and denser functional expression of NSC(MS) in small pulmonary arteries might suggest an adaptive tuning for the relatively low pulmonary blood pressure in vivo.
ISSN
1018-1172 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16733370

http://hdl.handle.net/10371/28483
DOI
https://doi.org/10.1159/000093607
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Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Physiology (생리학교실)Journal Papers (저널논문_생리학교실)
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