S-Space College of Medicine/School of Medicine (의과대학/대학원) Nuclear Medicine (핵의학전공) Journal Papers (저널논문_핵의학전공)
Cerebral glucose metabolism in oculopalatal tremor
- Moon, S Y; Cho, S S; Kim, Y K; Kim, S E; Kim, J H; Kim, J S
- Issue Date
- Blackwell Publishing
- Eur J Neurol. 2008 Jan;15(1):42-9. Epub 2007 Nov 14.
- Adult; Aged; Brain/metabolism/physiopathology/radionuclide imaging; Fluorodeoxyglucose F18/diagnostic use; Functional Laterality/physiology; Glucose/*metabolism; Humans; Male; Middle Aged; Myoclonus/*metabolism/physiopathology/radionuclide imaging; Neural Pathways/metabolism/physiopathology/radionuclide imaging; Olivary Nucleus/pathology/physiopathology; Pons/metabolism/physiopathology/radionuclide imaging; Positron-Emission Tomography; Predictive Value of Tests; Sensitivity and Specificity; Thalamus/metabolism/physiopathology/radionuclide imaging; Tremor/*metabolism/physiopathology/radionuclide imaging
- No study adopted the statistical parametric mapping (SPM) analyses of (18)F-fluorodeoxy glucose (FDG) PET in a large number of patients with oculopalatal tremor (OPT). To determine regional cerebral glucose metabolism in patients with OPT, nine patients with OPT underwent FDG-PET of the brain. Their glucose metabolism was compared with that of 50 normal controls (NC) by using SPM analyses. Three patients had bilateral and six showed unilateral pseudohypertrophic degeneration of the inferior olivary nucleus (ION) on MRI. Compared with NC, OPT patients did not show any metabolic derangement in the anterolateral medulla where the pseudohypertrophic ION locates. Instead, six patients with unilateral ION changes had hypometabolism in ipsilesional pontine tegmentum and hypermetabolism in contralesional thalamus. Their metabolic changes did not depend on the lateralization of ION changes. Our study failed to present any metabolic evidence for the role of ION in the generation of OPT. In part, the failure might originate from the different pathomechanism between OPT and pure palatal tremor or sensitivity/specificity issues of PET and SPM analyses. But, our results suggest that impaired cell groups of the paramedian tract and thalamic tremor cells may contribute to the generation of OPT.
- 1468-1331 (Electronic)
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