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Asymmetrically altered integrity of cingulum bundle in posttraumatic stress disorder

Cited 66 time in Web of Science Cited 74 time in Scopus
Authors
Kim, Seog Ju; Jeong, Do-Un; Sim, Minyoung E; Bae, Soojeong C; Chung, Ain; Kim, Minue J; Chang, Kee Hyun; Ryu, Jeong; Renshaw, Perry F; Lyoo, In Kyoon
Issue Date
2007-01-03
Publisher
Karger
Citation
Neuropsychobiology. 2006;54(2):120-5. Epub 2007 Jan 3.
Keywords
AdultBrain MappingCase-Control StudiesChi-Square DistributionDiffusion Magnetic Resonance ImagingFemaleGyrus Cinguli/*pathologyHumansMagnetic Resonance Imaging, CineMaleMiddle AgedStress Disorders, Post-Traumatic/*pathology
Abstract
Previously, our group reported the altered white matter tract integrity of the left anterior cingulate in posttraumatic stress disorder (PTSD) in whole-brain exploration. Current study intended to explore whether the alteration was more prominent in any specific regions of the cingulum bundle. Diffusion tensor images of 21 PTSD subjects and 21 healthy comparison subjects were acquired. Eight isocubic regions of interest (ROIs), i.e. bilateral rostral, subgenual, dorsal, and upper cingulum bundle, were selected. Fractional anisotropy values in each ROI, which indicate the white matter tract integrity, were measured and compared between groups. Relative to comparison subjects, PTSD subjects had significantly smaller fractional anisotropy values in the left side of rostral, subgenual and dorsal cingulum bundle (26.7, 25.0, 22.2% decrease, respectively), but not in the right side ROIs. We report an asymmetrical alteration of the cingulum bundle in PTSD.
ISSN
0302-282X (Print)
Language
English
URI
http://content.karger.com/produktedb/produkte.asp?typ=pdf&file=000098262

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17199097

http://hdl.handle.net/10371/28929
DOI
https://doi.org/10.1159/000098262
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College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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