S-Space College of Medicine/School of Medicine (의과대학/대학원) Anatomy (해부학전공) Journal Papers (저널논문_해부학전공)
Developmental expression of transferrin binding protein in oligodendrocyte lineage cells of the embryonic chick spinal cord
- Park, Sang Wook; Lim, Ha Seong; Roh, Eun Jung; Kim, Dong Woon; Jeon, Gye Sun; Cho, Sa Sun
- Issue Date
- Springer Verlag
- Neurochem Res. 2007 Jan;32(1):11-8. Epub 2006 Dec 6.
- Animals; Blotting, Western; Cell Lineage; Chick Embryo; *Gene Expression Regulation, Developmental; Immunohistochemistry; Microscopy, Fluorescence; Oligodendroglia/cytology/immunology/*metabolism; Spinal Cord/embryology; Transferrin-Binding Proteins/*biosynthesis
- Oligodendrocytes develop from precursor cells in the neuroepithelium of the ventral ventricular zone. Oligodendrocytes in the different stages of development are characterized by expression of a number of different marker molecules such as myelin genes, growth factors, and specific antigens. We have previously identified that transferrin binding protein (TfBP), a member of heat shock protein 90 families, is a novel avian ER-associated membrane protein that is specifically localized in oligodendrocytes in adult chicken CNS. In this study we describe the developmental expression of TfBP in the embryonic chick spinal cord. A few, distinct, TfBP+ cells appeared at the lateral margin of the subventricular neuroepithelium of the spinal cord at E7. Thereafter, some TfBP+ cells, exhibited a migrative form of unipolar or bipolar shape occurred around E8 in the mantle layer, midway between the neuroepithelium and the marginal layer of the primitive spinal cord. Thereafter, the TfBP+ cells rapidly increased in number as well as their staining intensity, and overall distribution of TfBP+ cells at E15 was comparable to that of a mature spinal cord. Our observations suggest that TfBP is expressed in the subpopulation of oligodendrocyte lineage in the development and a putative role of TfBP in relation to transferrin and iron trafficking is considered.
- 0364-3190 (Print)
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