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Developmental expression of transferrin binding protein in oligodendrocyte lineage cells of the embryonic chick spinal cord
Cited 4 time in
Web of Science
Cited 4 time in Scopus
- Authors
- Issue Date
- 2006-12-08
- Publisher
- Springer Verlag
- Citation
- Neurochem Res. 2007 Jan;32(1):11-8. Epub 2006 Dec 6.
- Keywords
- Animals ; Blotting, Western ; Cell Lineage ; Chick Embryo ; Immunohistochemistry ; Microscopy, Fluorescence ; Oligodendroglia/cytology/immunology/*metabolism ; Spinal Cord/embryology ; Transferrin-Binding Proteins/*biosynthesis ; Gene Expression Regulation, Developmental
- Abstract
- Oligodendrocytes develop from precursor cells in the neuroepithelium of the ventral ventricular zone. Oligodendrocytes in the different stages of development are characterized by expression of a number of different marker molecules such as myelin genes, growth factors, and specific antigens. We have previously identified that transferrin binding protein (TfBP), a member of heat shock protein 90 families, is a novel avian ER-associated membrane protein that is specifically localized in oligodendrocytes in adult chicken CNS. In this study we describe the developmental expression of TfBP in the embryonic chick spinal cord. A few, distinct, TfBP+ cells appeared at the lateral margin of the subventricular neuroepithelium of the spinal cord at E7. Thereafter, some TfBP+ cells, exhibited a migrative form of unipolar or bipolar shape occurred around E8 in the mantle layer, midway between the neuroepithelium and the marginal layer of the primitive spinal cord. Thereafter, the TfBP+ cells rapidly increased in number as well as their staining intensity, and overall distribution of TfBP+ cells at E15 was comparable to that of a mature spinal cord. Our observations suggest that TfBP is expressed in the subpopulation of oligodendrocyte lineage in the development and a putative role of TfBP in relation to transferrin and iron trafficking is considered.
- ISSN
- 0364-3190 (Print)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17151919
https://hdl.handle.net/10371/29054
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