S-Space College of Medicine/School of Medicine (의과대학/대학원) Internal Medicine (내과학전공) Journal Papers (저널논문_내과학전공)
Polymorphisms of the MCP-1 and HSP70-2 genes in Korean patients with alcoholic chronic pancreatitis
- Lee, Sang Hyub; Ryu, Ji Kon; Jeong, Ji Bong; Lee, Kyeung-Yeup; Woo, Sang Myung; Park, Joo Kyung; Yoo, Ji Won; Kim, Yong-Tae; Yoon, Yong Bum
- Issue Date
- Springer Verlag
- Dig Dis Sci. 2008 Jun;53(6):1721-7.
- Chemokine CCL2/*genetics; Chi-Square Distribution; Gene Frequency; Genetic Predisposition to Disease; Genotype; HSP70 Heat-Shock Proteins/*genetics; Humans; Korea/epidemiology; Male; Middle Aged; Pancreatitis, Alcoholic/epidemiology/*genetics; Pancreatitis, Chronic/epidemiology/*genetics; *Polymorphism, Genetic; Prevalence; Prospective Studies
- Alcoholic chronic pancreatitis (ACP) develops in only a small number of alcoholics. Monocyte chemotactic protein-1 (MCP-1) and heat-shock protein 70-2 (HSP70-2) polymorphisms have been reported to be associated with the severity of acute pancreatitis. However, their role in pathogenesis of ACP has not been investigated. A genetic association study for susceptibility and severity was performed on 79 male Korean ACP patients and 82 male controls. MCP-1 and HSP70-2 genotypes were determined using a fluorescence polarization detection method. The genotypes and G allele frequencies were no different in patients and controls. However, MCP-1 G allele had an effect on the development of severe ACP, when its frequency was compared in mild to moderate and severe ACP (29.6 vs. 56.0%, P = 0.02). The MCP-1 and HSP70-2 polymorphisms do not play a major role in the development of ACP in Koreans. However, MCP-1 polymorphism may be associated with the severity of ACP.
- 0163-2116 (Print)
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