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Identification of a novel role of T cells in postnatal vasculogenesis: characterization of endothelial progenitor cell colonies

Cited 179 time in Web of Science Cited 182 time in Scopus
Authors
Hur, Jin; Yang, Han-Mo; Yoon, Chang-Hwan; Lee, Choon-Soo; Park, Kyung-Woo; Kim, Ji-Hyun; Kim, Tae-Youn; Kim, Ju-Young; Kang, Hyun-Jae; Chae, In-Ho; Oh, Byung-Hee; Park, Young-Bae; Kim, Hyo-Soo
Issue Date
2007-10-03
Publisher
American Heart Association
Citation
Circulation. 2007 Oct 9;116(15):1671-82. Epub 2007 Oct 1.
Keywords
Antigens, CD/analysisAntigens, CD3/analysisAntigens, CD31/analysisBiological MarkersCardiovascular Diseases/*pathologyCell DifferentiationEndothelium, Vascular/*growth & development/physiologyHumansNeovascularization, PhysiologicStem Cells/cytology/immunology/*physiologyT-Lymphocytes/cytology/immunology/*physiology
Abstract
BACKGROUND: The colony number of early endothelial progenitor cells (EPCs) has been used as a quantitative indicator of the number of EPCs in the blood or as a biological marker of cardiovascular diseases. In the present study, we found a subset of T cells that were localized at the center of the EPC colony and played a pivotal role in colony formation and differentiation of early EPCs. METHODS AND RESULTS: We found that CD3+ CD31+ CXCR4+ T cells (referred to as angiogenic T cells in the present study) constituted the center of EPC colonies during cultures of human peripheral blood mononuclear cells. These angiogenic T cells were required for colony formation and differentiation of early EPCs. They secreted high levels of angiogenic cytokines such as vascular endothelial growth factor, interleukin-8, and matrix metalloproteinases. Angiogenic T cells showed superior angiogenic potential to the other subset of T cells in the experiments with regard to Matrigel tube formation, adhesion, transendothelial migration, and collagen invasion assay, mainly through the stromal cell-derived factor 1/CXCR-4 axis. Furthermore, angiogenic T cells enhanced endothelial cell proliferation and function. In vivo study showed that angiogenic T cells play an important role in the process of vessel formation. Clinical study showed that the level of angiogenic T cells in the peripheral blood was well correlated with EPC colony numbers and had inverse relationships with age and the number of risk factors for coronary artery disease. CONCLUSIONS: These findings suggest that angiogenic T cells could be a potential therapeutic target for ischemic cardiovascular diseases.
ISSN
1524-4539 (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17909106

https://hdl.handle.net/10371/29533
DOI
https://doi.org/10.1161/CIRCULATIONAHA.107.694778
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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