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Increased white matter hyperintensities in male methamphetamine abusers

Cited 54 time in Web of Science Cited 60 time in Scopus
Authors
Bae, Soojeong C; Lyoo, In Kyoon; Sung, Young Hoon; Yoo, Jaeun; Chung, Ain; Yoon, Su-Jung; Kim, Dai-Jin; Hwang, Jaeuk; Kim, Seog Ju; Renshaw, Perry F
Issue Date
2005-07-12
Publisher
Elsevier
Citation
Drug Alcohol Depend. 2006 Jan 4;81(1):83-8. Epub 2005 Jul 6.
Keywords
AdultAmphetamine-Related Disorders/*pathologyBrain/pathologyCerebral Ventricles/pathologyDementia, Vascular/*chemically induced/pathologyDemyelinating Diseases/*chemically induced/pathologyDose-Response Relationship, DrugHumansKorea*Magnetic Resonance ImagingMaleMethamphetamine/*toxicityMidline Thalamic Nuclei/pathologyNeurotoxicity Syndromes/*pathologyReference ValuesRisk FactorsStatistics as Topic
Abstract
BACKGROUND: The current study was conducted to compare the prevalence, severity, and location of white matter signal hyperintensities (WMH) on brain magnetic resonance (MR) imaging in methamphetamine (MA) abusers. METHODS: Thirty-three MA abusers and 32 age- and gender-matched healthy comparison subjects were studied. Axial T-2 weighted images and fluid attenuated inversion recovery axial images were obtained using 3.0 T MR scanner. The severity of WMH was assessed separately for deep and periventricular WMH. Ordinal logistic regression models were used to assess the odds ratio for WMH. RESULTS: MA abusers had greater severity of WMH than the healthy comparison subjects (odds ratio: 7.06, 8.46, and 4.56 for all, deep, and periventricular WMH, respectively). Severity of deep WMH correlated with total cumulative dose of MA (p = 0.027). Male MA abusers had greater severity of WMH than female MA abusers (odds ratio = 10.00). While male MA abusers had greater severity of WMH than male comparison subjects (odds ratio = 18.86), there was no significant difference in WMH severity between female MA abusers and female comparison subjects. CONCLUSIONS: The current study reports increased WMH in MA abusers, which may be related to MA-induced cerebral perfusion deficits. In addition, female MA abusers had less severe WMH than male MA abusers, possibly due to estrogen's protective effect against ischemic or neurotoxic effects of MA.
ISSN
0376-8716 (Print)
Language
English
URI
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T63-4GJVB5D-1&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=b3351ec22a3b9a2f477a7d23d83dc4ae

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16005161

https://hdl.handle.net/10371/29544
DOI
https://doi.org/10.1016/j.drugalcdep.2005.05.016
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College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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