S-Space College of Medicine/School of Medicine (의과대학/대학원) Anesthesiology and Pain Medicine (마취통증의학전공) Journal Papers (저널논문_마취통증의학전공)
Fentanyl reduces desflurane-induced airway irritability following thiopental administration in children
- Lee, J.; Oh, Y.; Kim, C.; Kim, S.; Park, H.; Kim, H.
- Issue Date
- Acta Anaesthesiol Scand. 2006 Oct;50(9):1161-4.
- Analgesics, Opioid/adverse effects/*therapeutic use; Anesthesia, General/*adverse effects; Anesthetics, Inhalation/*adverse effects; Apnea/chemically induced/drug therapy; Blood Pressure/physiology; Child; Child, Preschool; Cough/chemically induced/drug therapy; Double-Blind Method; Electrocardiography; Female; Fentanyl/adverse effects/*therapeutic use; Heart Rate/physiology; Humans; Hypnotics and Sedatives/*adverse effects; Injections, Intravenous; *Irritants; Isoflurane/adverse effects/*analogs & derivatives; Male; Mucus/secretion; Thiopental/*adverse effects
- BACKGROUND: Airway irritation is a major drawback of desflurane anesthesia. This study was designed to evaluate the effect of intravenous fentanyl given before thiopental induction on airway irritation caused by a stepwise increase in desflurane in children. METHODS: Eighty children (2-8 years) were enrolled in a randomized, double-blind study. Forty received saline and 40 received 2 microg/kg of fentanyl intravenously; this was followed by thiopental sodium 5 mg/kg in both groups. Patients were assistant-ventilated with desflurane 1%, which was then increased by 1% every six breaths up to 10%. During this period, cough, secretion, excitation and apnea were graded and the desflurane concentration at which airway irritation symptoms first occurred was recorded. The results were analyzed using Pearson's chi-squared test. RESULTS: The incidence of typical airway irritation events was lower with fentanyl than with saline (cough, 2.5% vs. 42.5%; secretion, 27.5% vs. 82.5%; excitation, 10% vs. 82.5%; apnea, 20% vs. 65%; P < 0.05). The mean expired desflurane concentration at which the first airway irritation symptom occurred was greater with fentanyl than with saline (7.3% vs. 5.5%, P < 0.05). CONCLUSIONS: Intravenous fentanyl in children reduces airway complications caused by desflurane.
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